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中华临床实验室管理电子杂志 ›› 2019, Vol. 07 ›› Issue (01) : 2 -4. doi: 10.3877/cma.j.issn.2095-5820.2019.01.002

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Epstein-Barr病毒感染机制
孟硕1, 王昭1,()   
  1. 1. 100050 北京,首都医科大学附属北京友谊医院血液科
  • 收稿日期:2018-04-26 出版日期:2019-02-28
  • 通信作者: 王昭
  • 基金资助:
    北京市医院管理局"杨帆"计划临床医学发展专项(ZYLX201702); 北京市科委首都特色项目(Z151100004015172); 首都卫生发展科研专项项目(首发2016-2-2017); 首都医科大学基础-临床科研合作基因(重点-16JL02); 北京市自然科学基金(7172058)

The mechanism of Epstein-Barr virus infection

Shuo Meng1, Zhao Wang1,()   

  1. 1. Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Received:2018-04-26 Published:2019-02-28
  • Corresponding author: Zhao Wang
  • About author:
    Corresponding author: Wang Zhao, Email:
引用本文:

孟硕, 王昭. Epstein-Barr病毒感染机制[J]. 中华临床实验室管理电子杂志, 2019, 07(01): 2-4.

Shuo Meng, Zhao Wang. The mechanism of Epstein-Barr virus infection[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2019, 07(01): 2-4.

爱泼斯坦-巴尔病毒(Epstein-Barr virus,EBV)是一种感染人类的γ疱疹病毒。其生命周期包括潜伏期和裂解期。EBV主要靶点是B淋巴细胞,也可感染上皮细胞、T淋巴细胞和自然杀伤细胞。感染宿主后,EBV在淋巴细胞或上皮细胞中潜伏,同时产生多种潜伏感染相关蛋白,以协助免疫逃逸,参与多种恶性肿瘤及非感染性的淋巴增殖性疾病的发生。本文将在EBV感染途径、感染后病毒的生命周期以及易感性等方面进行综述。

Epstein-Barr virus (EBV) is a human gamma herpes virus. Its bipartite life cycle includes latent and lytic stages. Although the main target of EBV is B lymphocytes, it can also infect epithelial cells, T lymphocytes and natural killer cells. After infection, the virus is latent in lymphocytes or epithelial cells, and products a variety of latent infection-associated proteins to assist immune escape and participate in the occurrence of various malignant tumors and non-infectious lymphoproliferative diseases. This article will review the aspects of the EBV infection pathway, the life cycle and susceptibility of the virus.

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