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中华临床实验室管理电子杂志 ›› 2019, Vol. 07 ›› Issue (01) : 17 -21. doi: 10.3877/cma.j.issn.2095-5820.2019.01.005

所属专题: 文献

综述

microRNA在HIV-1型感染及其相关疾病中的研究进展
闫新丽1, 王玉明2, 李晓非1,(), 张润武1, 王红英1   
  1. 1. 650041,昆明市第三人民医院检验科
    2. 650101,昆明医科大学第二附属医院
  • 收稿日期:2018-08-07 出版日期:2019-02-28
  • 通信作者: 李晓非

Research advance of microRNA in HIV-1 infection and related diseases

Xinli Yan1, Yuming Wang2, Xiaofei Li1,(), Runwu Zhang1, Hongying Wang1   

  1. 1. Department of Laboratory Medicine, The Third People′s Hospital of Kunming City, Kunming 650041, China
    2. The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China
  • Received:2018-08-07 Published:2019-02-28
  • Corresponding author: Xiaofei Li
  • About author:
    Corresponding author: Li Xiaofei, Email:
引用本文:

闫新丽, 王玉明, 李晓非, 张润武, 王红英. microRNA在HIV-1型感染及其相关疾病中的研究进展[J]. 中华临床实验室管理电子杂志, 2019, 07(01): 17-21.

Xinli Yan, Yuming Wang, Xiaofei Li, Runwu Zhang, Hongying Wang. Research advance of microRNA in HIV-1 infection and related diseases[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2019, 07(01): 17-21.

微小RNA(microRNA, miRNA)是一种重要的转录后基因表达调节因子,其表达谱的变化与许多人类病理学有关。miRNA与人类免疫缺陷病毒(human immunodeficiency virus,HIV)之间的相互关系已成为全球研究的热点之一。本文主要从miRNA对HIV-1病毒的转录复制、潜伏感染的影响,miRNA在HIV-1相关疾病中的研究,及其对人类获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)的治疗前景进行综述。

MicroRNA (miRNA) is an important post-transcriptional gene expression regulator, and its expression profile changes are related to many human pathology. The correlation between miRNA and human immunodeficiency virus 1 (HIV-1) has become one of the hot spots in global research. In this paper, the effects of miRNA on the transcription replication and latent infection of HIV-1 virus, the study of miRNA in HIV-1 related diseases and the therapeutic prospects of AIDS are reviewed.

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