2020年开始的新型冠状病毒感染疫情给全国学校线下教学带来不利影响。全员核酸检测在很多地区开展，而其检测原理来自于分子诊断学的教学内容，分子诊断学是一门理论性和应用性很强的医学检验技术专业核心课程，疫情防控给高校医学专业课程教学带来了挑战，也带来了新的关注点和教学契机。本文通过具体教学实践，从制定教学方案、优化教学内容、开展课程思政、引导学生科研思维４个方面，探索在疫情期间紧密结合热点时事开展课程教学的改革，同时对教学效果进行了评价和思考，为后续教学实施中提升分子诊断学的教学效果提供了思路和参考。

The sudden outbreak of the novel coronavirus pneumonia in the first half of 2020 has brought challenges to the teaching of medical courses in colleges. Whole-body nucleic acid testing is carried out in many areas, and its detection principle comes from the teaching content of Molecular Diagnostics. It is a core course of medical laboratory technology with strong theoretical and practical application. The epidemic prevention and control has brought challenges to the teaching of medical courses in colleges and universities, as well as new concerns and teaching opportunities.Through specific teaching practices, this article explores the methods of conducting curriculum teaching in close integration with hot current events during the epidemic from four aspects: formulating teaching plans, optimizing teaching content, developing curriculum ideology, and guiding students to conduct scientific research. To explore the reform of course teaching in close combination with hot current events during the epidemic. At the same time, the teaching effect were evaluated and evaluated. Thoughts provide ideas and references for improving the teaching effect of Molecular Diagnostics in subsequent teaching implementation.