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中华临床实验室管理电子杂志 ›› 2025, Vol. 13 ›› Issue (02) : 106 -110. doi: 10.3877/cma.j.issn.2095-5820.2025.02.007

综述

溶瘤病毒在膀胱癌治疗中的研究现状及进展
陈金龙1, 管晓东2,()   
  1. 1. 046000 山西长治,长治医学院第一临床学院
    2. 044000 山西运城,山西医科大学附属运城市中心医院泌尿外科
  • 收稿日期:2024-07-21 出版日期:2025-05-28
  • 通信作者: 管晓东

Research status and progress of oncolytic virus in the treatment of bladder cancer

Jinlong Chen1, Xiaodong Guan2,()   

  1. 1. The First Clinical College of Changzhi Medical College, Changzhi Shanxi 046000, China
    2. Department of Urology, Yuncheng Central Hospital Affiliated to Shanxi Medical University, Yuncheng Shanxi 044000, China
  • Received:2024-07-21 Published:2025-05-28
  • Corresponding author: Xiaodong Guan
引用本文:

陈金龙, 管晓东. 溶瘤病毒在膀胱癌治疗中的研究现状及进展[J/OL]. 中华临床实验室管理电子杂志, 2025, 13(02): 106-110.

Jinlong Chen, Xiaodong Guan. Research status and progress of oncolytic virus in the treatment of bladder cancer[J/OL]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2025, 13(02): 106-110.

膀胱癌是泌尿系统最常见的恶性肿瘤。传统的膀胱癌治疗方式主要依据肿瘤的浸润程度而定。治疗非肌层浸润性膀胱癌(NMIBC)多采用经尿道膀胱肿瘤电切术,术后用膀胱灌注治疗预防肿瘤复发;而肌层浸润性尿路上皮癌一般采用全膀胱切除术。无论是针对NMIBC还是肌层浸润性膀胱癌(MIBC),传统治疗都存在容易复发的问题。随着癌症分子生物学、分子免疫学、分子遗传学及相关学科的发展,溶瘤病毒已在膀胱癌动物实验中显示出良好疗效,所以溶瘤病毒疗法为膀胱癌治疗带来新思路。本文将对溶瘤病毒在膀胱癌中的研究现状和进展进行综述。

Bladder cancer remains the most prevalent malignant tumor in the urinary system.Current treatment strategies are primarily determined by tumor invasiveness. Non-muscle-invasive bladder cancer (NMIBC) typically undergoes transurethral resection with adjuvant intravesical therapy, while muscle-invasive urothelial carcinoma (MIBC) requires radical cystectomy. However, both approaches face significant challenges with disease recurrence. Recent advances in cancer molecular biology, immunology, and genetics have revealed the therapeutic potential of oncolytic viruses, with promising efficacy demonstrated in preclinical bladder cancer models. This emerging modality offers novel treatment opportunities for bladder cancer management. This review comprehensively examines the current research status and recent progress in oncolytic virotherapy for bladder cancer, highlighting its potential to address the limitations of conventional treatments.

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