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中华临床实验室管理电子杂志 ›› 2026, Vol. 14 ›› Issue (01) : 74 -80. doi: 10.3877/cma.j.issn.2095-5820.2026.01.013

综述

流行性感冒病毒继发细菌感染流行病学和致病机制研究进展
高桃桃, 刘立福, 陈茵桐, 周颖璇, 邓小燕, 梁晓丽()   
  1. 511436 广东 广州,广州医科大学金域检验学院
  • 收稿日期:2025-05-08 出版日期:2026-02-28
  • 通信作者: 梁晓丽
  • 基金资助:
    国家自然科学基金青年项目(82204732); 广东省自然科学基金面上项目(2024A1515011207); 2025年大学生创新训练项目(02-408-2501-2056)

Research progress on secondary bacterial infection following influenza virus infection

Taotao Gao, Lifu Liu, Yintong Chen, Yingxuan Zhou, Xiaoyan Deng, Xiaoli Liang()   

  1. KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou Guangdong 511436, China
  • Received:2025-05-08 Published:2026-02-28
  • Corresponding author: Xiaoli Liang
引用本文:

高桃桃, 刘立福, 陈茵桐, 周颖璇, 邓小燕, 梁晓丽. 流行性感冒病毒继发细菌感染流行病学和致病机制研究进展[J/OL]. 中华临床实验室管理电子杂志, 2026, 14(01): 74-80.

Taotao Gao, Lifu Liu, Yintong Chen, Yingxuan Zhou, Xiaoyan Deng, Xiaoli Liang. Research progress on secondary bacterial infection following influenza virus infection[J/OL]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2026, 14(01): 74-80.

流行性感冒(流感)病毒继发细菌感染是流感最常见的严重并发症,显著增加流感相关重症和死亡风险。本文综述了该并发症的流行病学特征和致病机制:常见致病菌株为肺炎链球菌、金黄色葡萄球菌和流感嗜血杆菌,继发感染与高病死率密切相关;流感病毒可通过多种机制促进继发细菌感染,如病毒损伤上皮屏障、抑制宿主免疫以及病毒-细菌直接相互作用等。深入研究流感继发细菌感染的分子机制对于开发更有效的防治策略具有重要意义。

Influenza virus-associated secondary bacterial infection represents a major severe complication, significantly increasing the risk of critical illness and mortality. This review summarizes the epidemiological features and pathogenic mechanisms of this complication. The most frequently isolated bacterial pathogens are Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenzae, and such coinfections are strongly associated with high fatality rates. Influenza virus facilitates bacterial superinfection through multiple mechanisms, including disruption of the epithelial barrier, suppression of innate immune responses, and direct interactions between viral and bacterial components. An in-depth understanding of the molecular mechanisms is crucial for developing more effective prevention and therapeutic strategies.

表1 自20世纪以来流感大流行的估计死亡率和感染率/%
表2 流感大流行中细菌性共感染的流行病学特征汇总
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