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中华临床实验室管理电子杂志 ›› 2014, Vol. 02 ›› Issue (02) : 93 -97. doi: 10.3877/cma.j.jssn.2095-5820.2014.02.006

综述

载脂蛋白M 的调控与脂代谢相关疾病
刘茵茵1, 胡敏1,()   
  1. 1.410011 长沙,中南大学湘雅二医院检验科
  • 收稿日期:2014-05-03 出版日期:2014-05-28
  • 通信作者: 胡敏

Relationship between the regulation of apolipoprotein M and lipid metabolism related diseases

Yinyin Liu1, Min Hu1,()   

  1. 1.Department of Clinical Laboratory, the Second Xiangya Hospital of Central South University, Changsha 410011, China
  • Received:2014-05-03 Published:2014-05-28
  • Corresponding author: Min Hu
引用本文:

刘茵茵, 胡敏. 载脂蛋白M 的调控与脂代谢相关疾病[J/OL]. 中华临床实验室管理电子杂志, 2014, 02(02): 93-97.

Yinyin Liu, Min Hu. Relationship between the regulation of apolipoprotein M and lipid metabolism related diseases[J/OL]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2014, 02(02): 93-97.

载脂蛋白M(apolipoprotein M,apoM)是1999年发现的一种载脂蛋白,为脂蛋白超家族中的成员,相对分子量26 000。人apoM 主要表达于肝脏实质细胞和肾脏近端肾小管上皮细胞,少见于其他组织。目前,apoM 的基因结构和定位已比较明确,而调控机制十分复杂,有待进一步研究。血浆中apoM 主要存在于高密度脂蛋白(high density lipoprotein,HDL)颗粒中,与前β-HDL 的形成和胆固醇逆转运有密切关系。对apoM 的调控及功能的深入研究,将对与脂代谢相关疾病,如冠心病、糖尿病的研究提供新线索。

Apolipoprotein M (apoM) with molecular weight of 26 000, a kind of apolipoprotein found in 1999, is a member of the superfamily of lipid protein. ApoM is mainly expressed in human liver parenchymal cells and kidney proximal renal tubular epithelial cells, which is rarely expressed in the other tissues. Up to now, the structure and localization of the apoM gene is relatively clear; however, the regulation mechanism of apoM is very complex which need to be further studied. Plasma apoM mainly exists in the high density lipoprotein (HDL) particles, and is associated with the formation of pre-β-HDL and the reverse cholesterol transport. The further study of the regulation and function of apoM will provide more new clues for the study of diseases associated with lipid metabolism, such as coronary heart disease and diabetes.

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