切换至 "中华医学电子期刊资源库"

中华临床实验室管理电子杂志 ›› 2015, Vol. 03 ›› Issue (01) : 2 -5. doi: 10.3877/cma.j.jssn.2095-5820.2015.01.002

述评

肿瘤标志物在健康体检人群中的应用
周韵斓1, 沈立松1,()   
  1. 1.200092 上海交通大学医学院附属新华医院检验科
  • 收稿日期:2015-02-07 出版日期:2015-02-28
  • 通信作者: 沈立松

Tumor markers for cancer screening in general health examination

Yunlan Zhou1, Lisong Shen1,()   

  1. 1.Department of Clinical Laboratory, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200092,China
  • Received:2015-02-07 Published:2015-02-28
  • Corresponding author: Lisong Shen
引用本文:

周韵斓, 沈立松. 肿瘤标志物在健康体检人群中的应用[J/OL]. 中华临床实验室管理电子杂志, 2015, 03(01): 2-5.

Yunlan Zhou, Lisong Shen. Tumor markers for cancer screening in general health examination[J/OL]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2015, 03(01): 2-5.

肿瘤标志物检测因其采样便捷、经济有效,在肿瘤筛查中具有独到应用价值。除了少数标志物适合在无症状、一般风险的表观健康人群进行筛查外,绝大多数肿瘤标志物主要针对特定肿瘤的高危人群筛查。未来应用于健康体检的肿瘤标志物种类将不断丰富,有助于筛选出肿瘤高危人群,为肿瘤发病风险的预测和评估提供帮助。我国健康体检应用的肿瘤标志物在检测技术、适用指征、结果解读、医学伦理等方面需进一步完善。

Given their easy sampling and cost-effectiveness, tumor markers have unique values in cancer screening. However, screening should be carried out in high-risk populations for specific cancers;.most of the tumor markers are not recommended for mass screening in populations at average risk, except for those have good performances in early detection of cancers in asymptomatic individuals at average risk. In the future, a wide variety of tumor markers will be applied to general health examination, which will facilitate finding the high-risk groups of cancers, providing them with prediction and evaluation. Improvements in major issues of technology, indication, interpretation, regulations, and medical ethics are needed for the rational use of tumor markers for cancer screening in China.

1
Yang G, Wang Y, Zeng Y, et al. Rapid health transition in China,1990-2010: findings from the Global Burden of Disease Study 2010[J]. Lancet, 2013,381(9882):1987-2015.
2
Omata M, Lesmana LA, Tateishi R, et al. Pacific Association for the study of the liver consensus recommendations on hepatocellular carcinoma [J]. HepatolInt, 2010, 4(2):439-474.
3
European Association for the Study of the Liver, European Organization for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma[J]. J Hepatol, 2012,56(4):908-943.
4
Sturgeon CM, Duffy MJ, Hofmann BR, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in liver, bladder, cervical, and gastric cancers[J].Clin Chem, 2010,56(6):e1-e48.
5
Murphy JE, Ryan DP. American Society of Clinical Oncology 2010 colorectal update[J]. Expert Rev Anticancer Ther, 2010,10(9):1371-1373.
6
Shaukat A, Mongin SJ, Geisser MS, et al. Long-term mortality after screening for colorectal cancer[J]. N Engl J Med, 2013,369(12):1106-1114.
7
Lee JK, Liles EG, Bent S, et al. Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis[J].Ann Intern Med, 2014,160(3):171.
8
Imperiale TF, Ransohoff DF, Itzkowitz SH, et al. Multitarget stool DNA testing for colorectal-cancer screening[J]. N Engl J Med,2014,370(14):1287-1297.
9
Smith RA, Manassaram-Baptiste D, Brooks D, et al. Cancer screening in the United States, 2014: a review of current American Cancer Society guidelines and current issues in cancer screening[J]. CA Cancer J Clin, 2014,64(1):30-51.
10
Dinis-Ribeiro M, Yamaki G, Miki K, et al.Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening[J]. J Med Screen, 2004,11(3):141-147.
11
Hayes JH, Barry MJ. Screening for prostate cancer with the prostatespecific antigen test: a review of current evidence[J]. JAMA,2014,311(11):1143-1149.
12
Andriole GL, Crawford ED, Grubb RL 3rd, et al. Mortality results from a randomized prostate-cancer screening trial[J]. N Engl J Med,2009,360(13):1310-1319.
13
Schröder FH, Hugosson J, Roobol MJ, et al. Prostate-cancer mortality at 11 years of follow-up[J]. N Engl J Med, 2012,366(11): 981-990.
14
Steenbergen RD, Snijders PJ, Heideman DA, et al. Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions[J]. Nat Rev Cancer, 2014,14(6):395-405.
15
Buys SS, Partridge E, Black A, et al. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian(PLCO) Cancer Screening Randomized Controlled Trial[J]. JAMA,2011,305(22):2295-2303.
16
Anderson GL, McIntosh M, Wu L, et al. Assessing lead time of selected ovarian cancer biomarkers: a nested case-control study[J]. J Natl Cancer Inst, 2010,102(1):26-38.
17
Escudero JM, Auge JM, Filella X, et al. Comparison of serum human epididymis protein 4 with cancer antigen 125 as a tumor marker in patients with malignant and nonmalignant diseases[J]. ClinChem,2011,57(11):1534-1544.
18
Bauça JM, Martínez-Morillo E, Diamandis EP. Peptidomics of urine and other biofluids for cancer diagnostics[J]. ClinChem,2014,60(8):1052-1061.
19
Crowley E, Di Nicolantonio F, Loupakis F, et al. Liquid biopsy:monitoring cancer-genetics in the blood[J]. Nat Rev ClinOncol,2013,10(8):472-484.
20
Schwarzenbach H, Nishida N, Calin GA, et al. Clinical relevance of circulating cell-free microRNAs in cancer[J]. Nat Rev Clin Oncol,2014,11(3):145-156.
21
Moyer VA, US Preventive Services Task Force. Risk assessment,genetic counseling, and genetic testing for BRCA-related cancer in women: US Preventive Services Task Force recommendation statement[J]. Ann Intern Med, 2014,160(4):271-281.
22
Pavlou MP, Diamandis EP, Blasutig IM. The long journey of cancer biomarkers from the bench to the clinic[J]. Clin Chem,2013,59(1):147-157.
23
Morgan SR, Whiteley J, Donald E, et al. Comparison of KRAS mutation assessment in tumor DNA and circulating free DNA in plasma and serum samples[J]. Clin Med Insights Pathol, 2012,5:15-22.
24
Chrystoja CC, Diamandis EP. Whole genome sequencing as a diagnostic test: challenges and opportunities[J]. ClinChem,2014,60(5):724-733.
[1] 韩萌萌, 冯雪园, 马宁. 乳腺癌改良根治术后桡神经损伤1例[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 117-118.
[2] 李国新, 陈新华. 全腹腔镜下全胃切除术食管空肠吻合的临床研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 1-4.
[3] 陈方鹏, 杨大伟, 金从稳. 腹腔镜近端胃癌切除术联合改良食管胃吻合术重建His角对术后反流性食管炎的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 15-18.
[4] 许杰, 李亚俊, 韩军伟. 两种入路下腹腔镜根治性全胃切除术治疗超重胃癌的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 19-22.
[5] 李刘庆, 陈小翔, 吕成余. 全腹腔镜与腹腔镜辅助远端胃癌根治术治疗进展期胃癌的近中期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 23-26.
[6] 刘世君, 马杰, 师鲁静. 胃癌完整系膜切除术+标准D2根治术治疗进展期胃癌的近中期随访研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 27-30.
[7] 任佳, 马胜辉, 王馨, 石秀霞, 蔡淑云. 腹腔镜全胃切除、间置空肠代胃术的临床观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 31-34.
[8] 赵丽霞, 王春霞, 陈一锋, 胡东平, 张维胜, 王涛, 张洪来. 内脏型肥胖对腹腔镜直肠癌根治术后早期并发症的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 35-39.
[9] 吴晖, 佴永军, 施雪松, 魏晓为. 两种解剖入路下行直肠癌侧方淋巴结清扫的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 40-43.
[10] 周世振, 朱兴亚, 袁庆港, 刘理想, 王凯, 缪骥, 丁超, 汪灏, 管文贤. 吲哚菁绿荧光成像技术在腹腔镜直肠癌侧方淋巴结清扫中的应用效果分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 44-47.
[11] 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59.
[12] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[13] 徐逸男. 不同术式治疗梗阻性左半结直肠癌的疗效观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 72-75.
[14] 王露, 周丽君. 全腹腔镜下远端胃大部切除不同吻合方式对胃癌患者胃功能恢复、并发症发生率的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 92-95.
[15] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
阅读次数
全文


摘要