Progress in clinical applications of circulating miRNAs

doi:10.3877/cma.j.issn.2095-5820.2013.01.005

Abstract

Abstract:

Cancer is one of the leading cause of death in the world. Development of minimally invasive biomarkers for early detection of cancer is urgently needed to reduce the morbidity and mortality.MiRNAs may act as oncogenes or tumour-suppressors, participating in a series of biological activities including cell proliferation, differentiation, apoptosis and immune response. Recent studies have indicated that miRNAs take a stable, reproducible, cell-free form in the body fluid, and their unique expression patterns are correlated with certain human diseases, including various types of cancer. Circulating miRNAs enjoys the potential as blood-based fingerprints for cancer diagnosis, classification, therapeutic decisions, and prognosis.This article focuses on the origin, detecting method of circulating miRNAs and their potential as minimally invasive biomarkers for tumor malignancy.

Key words: Circulating microRNA, Biomarker, Tumor

Jiajia Yu, Shaoqing Ju. Progress in clinical applications of circulating miRNAs[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2013, 01(01): 20-25.

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References 43

1	Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell, 1993,75:843-854.
2	Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans[J]. Nature,2000,403:901-906.
3	Bushati N, Cohen SM. MicroRNA functions[J]. Annu Rev Cell Dev Biol, 2007, 23:175-205.
4	Lawrie CH, Gal S, Dunlop HM, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma[J]. Br J Haematol, 2008,141:672-675.
5	Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases[J].Cell Res, 2008,18:997-1006.
6	Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection[J]. Proc Natl Acad Sci U S A, 2008, 105:10513-10518.
7	Zen K, Zhang CY. Circulating microRNAs: a novel class of biomarkers to diagnose and monitor human cancers[J]. Med Res Rev,2012,32:326-348.
8	Valadi H, Ekstrom K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J]. Nat Cell Biol, 2007, 9:654-659.
9	Resnick KE, Alder H, Hagan JP, et al. The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform[J]. Gynecol Oncol, 2009,112:55-59.
10	Sun G, Wu X, Wang J, et al. A bias-reducing strategy in profiling small RNAs using Solexa[J]. RNA, 2011,17:2256-2262.
11	Beuvink I, Kolb FA, Budach W, et al. A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs[J]. Nucleic Acids Res, 2007,35:e52.
12	Lawrie CH, Soneji S, Marafioti T, et al. MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma[J]. Int J Cancer,2007,121:1156-1161.
13	Ng EK, Chong WW, Jin H, et al. Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening[J]. Gut, 2009,58:1375-381.
14	McDonald JS, Milosevic D, Reddi HV, et al. Analysis of circulating microRNA: preanalytical and analytical challenges[J]. Clin Chem,2011,57:833-840.
15	Perez-Andres M, Almeida J, Martin-Ayuso M, et al. Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease[J]. Int J Cancer, 2009,124:367-375.
16	Redova M, Poprach A, Nekvindova J, et al. Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma[J].J Transl Med, 2012,10:55.
17	Flamant S, Ritchie W, Guilhot J, et al. Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia[J].Haematologica, 2010,95:1325-1333.
18	Jones CI, Zabolotskaya MV, King AJ, et al. Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma[J].Br J Cancer, 2012, 107:1987-1996.
19	Huang JJ, Yu J, Li JY, et al. Circulating microRNA expression is associated with genetic subtype and survival of multiple myeloma[J].Med Oncol, 2012,29:2402-2408.
20	Yoshizawa S, Ohyashiki JH, Ohyashiki M, et al. Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders[J]. Blood Cancer J, 2012,2:e53.
21	Wang Q, Huang Z, Ni S, et al. Plasma miR-601 and miR-760 are novel biomarkers for the early detection of colorectal cancer[J]. PLoS One,2012,7:e44398.
22	Huang Z, Huang D, Ni S, et al. Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer[J]. Int J Cancer, 2010,127:118-126.
23	Kanaan Z, Roberts H, Eichenberger MR, et al. A Plasma MicroRNA Panel for Detection of Colorectal Adenomas[J]. Ann Surg, 2013,258:400-408.
24	Toiyama Y, Hur K, Tanaka K, et al, Serum miR-200c Is a Novel Prognostic and Metastasis-Predictive Biomarker in Patients With Colorectal Cancer[J]. Ann Surg, 2013, [Epub ahead of print].
25	Hu Z, Chen X, Zhao Y, et al. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer[J]. J Clin Oncol, 2010,28:1721-1726.
26	Mahn R, Heukamp LC, Rogenhofer S, et al. Circulating microRNAs(miRNA) in serum of patients with prostate cancer[J]. Urology,2011,77:1265 e1269-1216.
27	Brase JC, Johannes M, Schlomm T, et al. Circulating miRNAs are correlated with tumor progression in prostate cancer[J]. Int J Cancer,2011,128:608-616.
28	Schrauder MG, Strick R, Schulz-Wendtland R, et al. Circulating micro-RNAs as potential blood-based markers for early stage breast cancer detection[J]. PLoS One, 2012,7:e29770.
29	Asaga S, Kuo C, Nguyen T, et al. Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer[J]. Clin Chem,2011,57:84-91.
30	Tomimaru Y, Eguchi H, Nagano H, et al. Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma[J]. J Hepatol,2012,56:167-175.
31	Li LM, Hu ZB, Zhou ZX, et al. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma[J]. Cancer Res, 2010, 70:9798-97807.
32	Zhou J, Yu L, Gao X, et al. Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma[J]. J Clin Oncol,2011, 29:4781-4788.
33	Yu J, Wang Y, Dong R, et al. Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion[J]. J Cancer Res Clin Oncol, 2012, 138:671-674.
34	Iorio MV, Visone R, Di Leva G, et al. MicroRNA signatures in human ovarian cancer[J]. Cancer Res, 2007,67:8699-8707.
35	Kan CW, Hahn MA, Gard GB, et al. Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer[J]. BMC Cancer, 2012,12:627.
36	Liu R, Chen X, Du Y, et al. Serum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer[J]. Clin Chem, 2012,58:610-618.
37	Long G, Wang F, Duan Q, et al. Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction[J]. Int J Biol Sci, 2012,8:811-818.
38	Jaguszewski M, Osipova J, Ghadri JR, et al. A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction[J]. Eur Heart J, 2013. [Epub ahead of print].
39	Zhang Q, Kandic I, Faughnan ME, et al. Elevated circulating microRNA-210 levels in patients with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations: a potential new biomarker[J]. Biomarkers, 2013,18:23-29.
40	Hanke M, Hoefig K, Merz H, et al. A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer[J]. Urol Oncol, 2010,28:655-661.
41	Park NJ, Zhou H, Elashoff D, et al. Salivary microRNA: discovery,characterization, and clinical utility for oral cancer detection[J]. Clin Cancer Res, 2009,15:5473-5477.
42	Chim SS, Shing TK, Hung EC, et al. Detection and characterization of placental microRNAs in maternal plasma[J]. Clin Chem, 2008,54:482-490.
43	Zhao Z, Zhao Q, Warrick J, et al. Circulating microRNA miR-323-3p as a biomarker of ectopic pregnancy[J]. Clin Chem, 2012,58:896-905.

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