Advance on drug-resistant bacteria producing New Delhi metallo-β-lactamases-1

doi:10.3877/cma.j.issn.2095-5820.2014.03.006

Abstract

Abstract:

Drug-resistant bacteria producing New Delhi metallo-β-lactamase-1 (NDM-1) is a new challenge to the clinical treatment. It resistants to β-lactams including carbapenems, aminoglycosides, macrolides and quinolones and other antimicrobial agents. Only tigecycline and polymyxin maintained activities against the bacteria with NDM-1. This article introduced the molecular characteristics, mechanism of drug resistance, detecting methods,and prophylaxis and treatment of bacteria with NDM-1.

Key words: New Delhi metallo-β-lactamase-1, Drug resistance

Danping Lou, Fangyou Yu. Advance on drug-resistant bacteria producing New Delhi metallo-β-lactamases-1[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2014, 02(03): 158-161.

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