Research of new tumor biomarkers for early diagnosis of lung cancer

doi:10.3877/cma.j.issn.2095-5820.2017.04.004

Abstract

Abstract:

Lung cancer is one of the most common malignant worldwide, and one of common cause of camcer-related death, the most which seriously human health threaten. Early diagnosis of lung cancer is crucial to the good prognosis lung cancer, which can reduce the fatality rate significantly. Abnormal expression of markers in early lung cancer has become the most promising scientific exploration in the field of early diagnosis. At present, clinical serological markers of lung cancer include carcinoembryonic antigen (CEA), neuron specific enolization enzyme (NSE) and cytokeratin 19 fragment (CYFRA21-1), carbohydrate antigen 125(CA125), and pro-gastrin-releasing peptide(Pro-GRP). With the rapid development of molecular biology and high-throughput technology platform, new biomarkers, such as heat shock protein 90α (HSP90α), autoantibodies, circulating tumor DNA(ctDNA), microRNA(miRNA), and circulating tumor cells (CTC) are emerging. This paper mainly focuses on the functions and characteristics of new tumor biomarkers in the early diagnosis of lung cancer.

Key words: Lung cancer, Heat shock protein 90α, Autoantibody, Circulating tumor DNA, MicroRNA

Chuanxin Wang. Research of new tumor biomarkers for early diagnosis of lung cancer[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2017, 05(04): 212-216.

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References 42

1	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017[J]. CA Cancer J Clin, 2017,67(1):7-30.
2	Torre LA, Siegel RL, Jemal A. Lung cancer statistics[J]. Adv Exp Med Biol, 2016,893:1-19.
3	Lim E, Tay A, Von Der Thusen J, et al. Clinical results of microfluidic antibody-independent peripheral blood circulating tumor cell capture for thediagnosis of lung cancer[J]. J Thorac Cardiovasc Surg, 2013, 147(6):1936-1938.
4	Sawabata N. Prognosis of lung cancer patients in Japan according to data from the Japanese Joint Committee of Lung Cancer Registry[J]. Respir Investig, 2014,52(6):317-321.
5	Cho WC. Potentially useful biomarkers for the diagnosis, treatment and prognosis of lung cancer[J]. Biomed Pharmacother, 2007,61(9): 515-519.
6	McGregor HC, Short MA, McWilliams A, et al. Real-time endoscopic Raman spcetroscopy for in vivo early lung cancer detection[J]. Biophotonics, 2017,10(1):98-100.
7	Kumar N, Shahjaman M, Mollah MNH, et al. Serum and plasma metabolomic biomarkers for lung cancer[J]. Bioinformation, 2017,13(6):202-208.
8	Liu L, Teng J, Zhang L，et al. The Combination of the tumor markers suggests the histological diagnosis of lung cancer[J]. Biomed Res Int, 2017,2017:2013989.
9	Wang W, Xu X, Tian B, et al. The diagnostic value of serum tumor markers CEA, CA19-9, CA125, CA15-3, and TPS in metastatic breast cancer[J]. Clin Chim Acta, 2017,470:51-55.
10	Cho JY, Sung HJ. Proteomic approaches in lung cancer biomarker development[J]. Expert Rev Proteomics, 2009,6(1):27-42.
11	Takeuchi A, Oguri T, Sone K, et al. Predictive and prognostic value of CYFRA 21-1 for advanced non-small cell lung cancer treated with EGFR-TKIs[J]. Anticancer Res, 2017,37(10):5771-5776.
12	Zhang S, Zhao YF, Zhang MZ, et al. The diagnostic value of tumor markers in bronchoalveolar lavage fluid for the peripheral pulmonary carcinoma[J]. Clin Respir J, 2017,11(4):481-488.
13	Dong HM, Le YQ, Wang YH, et al. Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling[J]. Respir Res, 2017,18(1):111.
14	Shi Y, Liu X, Lou J, et al. Plasma levels of heat shock protein 90 alpha associated with lung cancer development and treatment responses[J]. Clin Cancer Res, 2014,20(23):6016-6022.
15	Kobayashi M, Nagashio R, Ryuge S, et al. Acquisition of useful sero-diagnostic autoantibodies using the same patients′sera and tumor tissues[J]. Biomed Res, 2014,35(2):133-143.
16	Macdonald IK, Parsy-Kowalska CB, Chapman CJ. Autoantibodies: opportunities for early cancer detection[J]. Trends Cancer, 2017, 3(3):198-213.
17	Broodman I, Lindemans J, van Sten J, et al. Serum protein markers for the early detection of lung cancer: a focus on autoantibodies[J]. J Proteome Res, 2017,16(1):3-13.
18	Chapman CJ, Murray A, McElveen JE, et al. Autoantibodies in lung cancer: possibilities for early detection and subsequent cure[J]. Thorax, 2008,63(3):228-233.
19	Boyle P, Chapman CJ, Holdenrieder S, et al. Clinical validation of an autoantibody test for lung cancer[J].Ann Oncol, 2011,22(2): 383-389.
20	Chapman CJ, Healey GF, Murray A, et al. EarlyCDT®-Lung test: improved clinical utility through additional autoantibody assays[J]. Tumour Biol, 2012,33(5):1319-1326.
21	Jett JR, Peek LJ, Fredericks L, et al. Audit of the autoantibody test, EarlyCDT®-lung, in 1600 patients: an evaluation of its performance in routine clinical practice[J]. Lung Cancer, 2014,83(1):51-55.
22	Sullivan FM, Farmer E, Mair FS, et al. Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial[J]. BMC Cancer, 2017,17(1):187.
23	Massion PP, Healey GF, Peek LJ，et al. Autoantibody signature enhances the positive predictive power of computed tomography and nodule-based risk models for detection of lung cancer[J]. J Thorac Oncol, 2017,12(3):578-584.
24	Jia S, Zhang R, Li Z，et al. Clinical and biological significance of circulating tumor cells, circulating tumor DNA, and exosomes as biomarkers in colorectal cancer[J]. Oncotarget, 2017,8(33):55632-55645.
25	Cheng F, Su L, Qian C. Circulating tumor DNA: a promising biomarker in the liquid biopsy of cancer[J]. Oncotarget, 2016,7(30):48832-48841.
26	Li M, Diehl F, Dressman D, et al. BEAMing up for detection and quantifcation of rare sequence variants[J]. Nat Methods, 2006,3(2): 95-97.
27	Reinert T, Schøler LV, Thomsen R, et al. Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery[J]. Gut, 2016,65(4):625-634.
28	Chen KZ, Lou F, Yang F, et al. Circulating tumor DNA detection in early-stage non-small cell lung cancer patients by targeted sequencing[J]. Sci Rep, 2016,6:31985.
29	Newman AM, Bratman SV, To J, et al. An ultrasensitive method for quantitating circulating tumor DNAwith broad patient coverage[J]. Nat Med, 2014,20(5):548-554.
30	Mishra PJ. MicroRNAs as promising biomarkers in cancer diagnostics[J]. Biomark Res, 2014,22(2):19.
31	Świtlik WZ, Szemraj J. Circulating miRNAs as non-invasive biomarkers for non-small cell lung cancer diagnosis, prognosis and prediction of treatment response[J]. Postepy Hig Med Dosw (Online), 2017,71:649-662.
32	Geng Q, Fan T, Zhang B et al. Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer[J]. Respir Res, 2014,25(15):149.
33	Heegaard NH, Schetter AJ, Welsh JA, et al. Circulating microRNA expression profiles in early stage nonsmall cell lung cancer[J]. Int J Cancer, 2012,130(6):1378-1386.
34	Foss KM, Sima C, Ugolini D, et al. miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer[J]. J Thorac Oncol, 2011,6(3):482-488.
35	Shen J, Liu Z, Todd NW, et al. Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers[J]. BMC Cancer, 2011,24(11):374.
36	Carter L, Rothwell DG, Mesquita B,et al. Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer[J]. Nat Med, 2017,23(1):114-119.
37	Hofman V, Bonnetaud C, llie MI, et al. Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker[J]. Clin Cancer Res, 2011,17(4):827-835.
38	Sleijfer S, Gratama JW, Sieuwei′ts AM，et al．Circulating tumor cell detection on its way to routine diagnostic implementation[J]. Eur J Cancer, 2007,43(18):2645-2650．
39	He W, Wang H, Hartmann LC, et al. In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry[J]. Proc Nat Acad Sci U S A, 2007,104(28):11760-11765.
40	Tanaka F, Yoneda K, Kondo N, et al. Circulating tumor cell as a diagnostic marker in primary lung cancer[J]. Clin Cancer Res, 2009, 15(22):6980-6986.
41	Carlsson A, Nair VS, Luttgen MS, et al. Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer[J]. J Thorac Oncol, 2014,9(8):1111-1119．
42	Ilie M, Hofman V, Long-Mira E，et al. ″Sentinel″ circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease[J]. PLoS One, 2014,9(10):e111597.

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