So far the existing cell block technique is complex and time-consuming, and the tissue block formation is not satisfying, This makes cell block section difficult and affects the application of routine hematoxylin-eosin (HE) staining and auxiliary diagnostics (immunohistochemistry and molecular pathological examination, etc.). We report a simple method to produce cell blocks. The cells are centrifugated and then soaked in 8% egg white, and then fixed with 10% neutral formalin. It only takes about three hours to produce cell blocks with good flexibility and unbreakable property. The blocks can be embedded, sectioned and stained with HE just like the surgical specimens, and molecular pathological examination also can be conducted. This improved method is easy to operate and no special instruments or reagents are needed. Thus, it is valuable for popularization and utilization.