Research advance of long non-coding RNA in diagnosis and prognosis of hepatocellular carcinoma

doi:10.3877/cma.j.issn.2095-5820.2019.03.001

Abstract

Abstract:

Hepatocellular carcinoma (HCC) is a type of malignancy with high incidence and mortality. Early diagnosis and treatment has become a key factor to improve the survival of the patients. Therefore, it is necessary to find an efficient and non-invasive marker for early diagnosis and prognosis in HCC. Long non-coding RNA (lncRNA) is a new hotspot in the research field of HCC in recent years, and in this paper we will review the value of lncRNA in the diagnosis and prognosis of hepatocellular carcinoma.

Key words: Long non-coding RNA, Hepatocellular carcinoma, Diagnosis, Prognosis

Lihong Zhang, Xuejun Dong, Hongbin Wang, Zhuan Zheng. Research advance of long non-coding RNA in diagnosis and prognosis of hepatocellular carcinoma[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2019, 07(03): 129-132.

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References 33

1	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016,66(2):115-132.
2	Gingold JA, Zhu D, Lee DF, et al. Genomic profiling and metabolic homeostasis in primary liver cancers[J]. Trends Mol Med, 2018,24(4):395-411.
3	Abdelaziz AO, Shousha HI. Survival and prognostic factors for hepatocellular carcinoma: an Egyptian multidisciplinary clinic experience[J]. Asian Pac J Cancer, 2014, 15(9):3915-3920.
4	Dalton-Fitzgerald E, Tiro J. Practice patterns and attitudes of primary care providers and barriers to surveillance of hepatocellular carcinoma in patients with cirrhosis[J]. Clin Gastroentero Hepatol, 2014,13(4):1542-3565.
5	Hung CH, Hu TH, Lu SN, et al. Circulating microRNAs as biomarkers for diagnosis of early hepatocellular carcinoma associated with hepatitis B virus[J]. Int J Cancer, 2016,138(3):714-720.
6	Zhang Z, Zhang Y, Wang Y, et al. Alpha-fetoprotein-L3 and Golgi protein 73 may serve as candidate biomarkers for diagnosing alpha-fetoprotein-negative hepatocellular carcinoma[J]. Onco Targets Ther, 2016,9:123-129.
7	Thurnherr T, Mah WC, Lei Z, et al. Differentially expressed MicroRNAs in hepatocellular carcinoma target genes in the genetic information processing and metabolism pathways[J]. Sci Rep, 2016,6:20065.
8	Guindon-Kezis KA, Mulder JE, Massey TE. In vivo treatment with aflatoxin B1 increases DNA oxidation, base excision repair activity and 8-oxoguanine DNA glycosylase 1 levels in mouse lung[J]. Toxicology, 2014,321:21-26.
9	Schmitt AM, Chang HY. Long noncoding RNAs in cancer pathways[J]. Cancer Cell, 2016,29:452-463.
10	Hauptman N, Glavac D. MicroRNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer[J]. Radiol Oncol, 2013,47(4):311-318.
11	Amaral PP, Leonardi T, Han N, et al. Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci[J]. Genome Biol, 2018,19(1):32.
12	Sun CC, Zhang L, Li G, et al. The lncRNA PDIA3P interacts with miR-185-5p to modulate oral squamous cell carcinoma progression by targeting cyclin D2[J]. Mol Ther Nucleic Acids, 2017,9:100-110.
13	Ji J, Tang J, Deng L, et al. LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway[J]. Oncotarget, 2015,6(40):42813-42824.
14	Huang MD, Chen WM, Qi FZ, et al. Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2[J]. Mol Cancer, 2015,14(8):165-174.
15	Tao R, Hu S, Wang S, et al. Association between indel polymorphism in the promoter region of lncRNA GAS5 and the risk of hepatocellular carcinoma[J]. Carcinogenesis, 2015,36(10):1136-1143.
16	Hu L, Ye H, Huang G, et al. Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21[J]. Tumour Biol, 2016,37(2):2691-2702.
17	Sheng L, Wu J, Gong X, et al. SP1-induced upregulation of lncRNA PANDAR predicts adverse phenotypes in retinoblastoma and regulates cell growth and apoptosis in vitro and in vivo[J]. Gene, 2018,668:140-145.
18	Liu J, Ben Q, Lu E, et al. Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer[J]. Cell Death Dis, 2018,9(2):168.
19	Peng W, Fan H. Long non-coding RNA PANDAR correlates with poor prognosis and promotes tumorigenesis in hepatocellular carcinoma[J]. Biomed Pharmacother, 2015,72:113-118.
20	Wang XS, Zhang Z, Wang HC, et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma[J]. Clin Cancer Res, 2006,12:4851-4858.
21	El-Tawdi AH, Matboli M, El-Nakeep S, et al. Association of long noncoding RNA and c-JUN expression in hepatocellular carcinoma[J]. Expert Rev Gastroenterol Hepatol, 2016,10(7):869-877.
22	Huppi K, Pitt JJ, Wahlberg BM, et al. The 8q24 gene desert: an oasis of non-coding transcriptional activity[J]. Front Genet, 2012,3:69.
23	Zhang Y, Dang YW, Wang X, et al. Comprehensive analysis of long non-coding RNA PVT1 gene interaction regulatory network in hepatocellular carcinoma using gene microarray and bioinformatics[J]. Am J Transl Res, 2017,9(9):3904-3917.
24	Gao JZ, Li J, Du JL, et al. Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence[J]. Oncol Lett, 2016,11:1791-1798.
25	Fujisaka Y, Iwata T, Tamai K, et al. Long non-coding RNA HOTAIR up-regulates chemokine (C-C motif) ligand 2 and promotes proliferation of macrophages and myeloid-derived suppressor cells in hepatocellular carcinoma cell lines[J]. Oncol Lett, 2018,15:509-514.
26	Wu Y, Lyu H, Liu H, et al. Downregulation of the long noncoding RNA GAS5-AS1 contributes to tumor metastasis in non-small cell lung cancer[J]. Sci Rep, 2016, 6:31093.
27	Wang Y, Jing W, Ma W, et al. Down-regulation of long non-coding RNA GAS5-AS1 and its prognostic and diagnostic significance in hepatocellular carcinoma[J]. Cancer Biomark, 2018, 22(2):227-236.
28	França GS, Vibranovski MD, Galante PA. Host gene constraints and genomic context impact the expression and evolution of human microRNAs[J]. Nat Commun, 2016,7:11438.
29	Dong Y, Yan W, Zhang SL, et al. Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy[J]. Oncotarget, 2017,8(69):114041-114049.
30	Wu Y, Huang C, Meng X, et al. Long noncoding RNA MALAT1: insights into its biogenesis and implications in human disease[J]. Curr Pharm Des, 2015,21(34):5017-5028.
31	Sonohara F, Inokawa Y, Hayashi M, et al. Prognostic value of long non-coding RNA HULC and MALAT1 following the curative resection of hepatocellular carcinoma[J]. Sci Rep, 2017,7(1):16142.
32	Chen SX, Yin JF, Lin BC, et al. Upregulated expression of long noncoding RNA SNHG15 promotes cell proliferation and invasion through regulates MMP2/MMP9 in patients with GC[J]. Tumour Biol, 2016,37(5):6801-6812.
33	Zhang JH, Wei HW, Yang HG. Long noncoding RNA SNHG15, a potential prognostic biomarker for hepatocellular carcinoma[J]. Eur Rev Med Pharmacol Sci, 2016, 20(9):1720-1724.

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