Analysis and countermeasures of EDTA-dependent pseudo thrombocytopenia

doi:10.3877/cma.j.issn.2095-5820.2020.03.002

Abstract

Abstract:

When the blood analyzer uses the anticoagulant EDTA-K₂ anticoagulant for blood cell analysis, sometimes platelet aggregation, resulting in a pseudo-low platelet count phenomenon, that is, EDTA-dependent pseudo thrombocytopenia (EDTA-dependent pseudo thrombocytopenia , EDTA-PTCP). If EDTA-PTCP was not discovered in time, it may cause misdiagnosis and even medical disputes in patients' clinical diagnosis and treatment. Therefore, the analysis of EDTA-PTCP related factors and the research of laboratory countermeasures have attracted much attention, especially the establishment of EDTA-PTCP laboratory solutions is more necessary. This article explores the factors related to the occurrence of EDTA-PTCP caused by EDTA in blood cell analyzers, and discusses the corresponding solutions and laboratory quality control.

Key words: EDTA-dependent pseudo thrombocytopenia, Blood cell analyzer, Platelets, Platelet aggregation, Discussion and analysis, Solutions

Yuanquan Liao, Xi Guo. Analysis and countermeasures of EDTA-dependent pseudo thrombocytopenia[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2020, 08(03): 133-139.

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