The role of lymphocyte indicators in the diagnosis and treatment of COVID-19

doi:10.3877/cma.j.issn.2095-5820.2021.03.009

Abstract

Abstract:

At present, the global spread of novel coronavirus (SARS-CoV-2) has posed a great threat to world public health. SARS-CoV-2 laboratory testing plays an important role in the diagnosis and prevention of disease. Through literature retrieval, data collection, analysis and induction, the role of commonly used lymphocyte indicators was elaborated in auxiliary diagnosis, prognosis assessment and efficacy monitoring of novel coronavirus infection, so as to provide reference for the treatment, prevention and control of COVID-19.

Key words: Coronaviridae, Lymphocyte

Meiwei Ning, Yajun Huang, Rong Zeng, Xiang Liu. The role of lymphocyte indicators in the diagnosis and treatment of COVID-19[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2021, 09(03): 169-173.

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References 40

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项目	作者	总体	非重症	重症	P值
WBC×10⁹/L	Qin^［8］	5.3(3.9~7.5)	4.9(3.7~6.1)	5.6(4.3~8.4)	＜0.001
	He^［16］	4.75(3.98~5.94)	4.74(4.04~5.76)	4.84(3.83~7.85)	0.021
	Zhu^［17］	5.00(4.20~6.80)	5.00(4.30~6.50)	5.35(4.13~7.53)	0.568
NEUT×10⁹/L	Qin^［8］	3.9(2.6~5.8)	3.2(2.1~4.4)	4.3(2.9~7.0)	＜0.001
	Liu^［18］	3.6(2.5~6.4)	3.1 (2.2~4.4)	6.7 (3.9~10.5)	＜0.001
	Zhu^［17］	3.37(2.54~4.55)	3.29(2.54~4.40)	3.89(2.25~6.57)	0.309
LYMPH×10⁹/L	Qin^［8］	0.9(0.6~1.2)	1.0(0.7~1.3)	0.8(0.6~1.1)	＜0.001
	Liu^［18］	0.97(0.65~1.42)	1.17(0.89~1.58)	0.60(0.38~0.76)	＜0.001
	Zhu^［17］	1.21(0.87~1.48)	1.23(0.90~1.53)	0.74(0.47~1.18)	0.004
NLR	Qin^［8］	4.2(2.5~7.7)	3.2(1.8~4.9)	5.5(3.3~10.0)	＜0.001
	Liu^［18］	3.6 (2.0~9.7)	2.6 (1.7~4.5)	10.4 (7.2~21.3)	＜0.001
	Zhu^［17］	2.91(1.95~4.15)	2.75(1.90~3.95)	4.24(3.00~10.87)	0.015

项目	作者	总体	非重症	重症	P值
WBC×10⁹/L	Qin^［8］	5.3(3.9~7.5)	4.9(3.7~6.1)	5.6(4.3~8.4)	＜0.001
	He^［16］	4.75(3.98~5.94)	4.74(4.04~5.76)	4.84(3.83~7.85)	0.021
	Zhu^［17］	5.00(4.20~6.80)	5.00(4.30~6.50)	5.35(4.13~7.53)	0.568
NEUT×10⁹/L	Qin^［8］	3.9(2.6~5.8)	3.2(2.1~4.4)	4.3(2.9~7.0)	＜0.001
	Liu^［18］	3.6(2.5~6.4)	3.1 (2.2~4.4)	6.7 (3.9~10.5)	＜0.001
	Zhu^［17］	3.37(2.54~4.55)	3.29(2.54~4.40)	3.89(2.25~6.57)	0.309
LYMPH×10⁹/L	Qin^［8］	0.9(0.6~1.2)	1.0(0.7~1.3)	0.8(0.6~1.1)	＜0.001
	Liu^［18］	0.97(0.65~1.42)	1.17(0.89~1.58)	0.60(0.38~0.76)	＜0.001
	Zhu^［17］	1.21(0.87~1.48)	1.23(0.90~1.53)	0.74(0.47~1.18)	0.004
NLR	Qin^［8］	4.2(2.5~7.7)	3.2(1.8~4.9)	5.5(3.3~10.0)	＜0.001
	Liu^［18］	3.6 (2.0~9.7)	2.6 (1.7~4.5)	10.4 (7.2~21.3)	＜0.001
	Zhu^［17］	2.91(1.95~4.15)	2.75(1.90~3.95)	4.24(3.00~10.87)	0.015

指标	作者	总体	非重症	重症	P值
CD3⁺/L	He^［16］	801 (496~1154)	1 066(804~1321)	305(198~525)	＜0.001
	Kong^［20］	700(400~1000)	900(600~1300)	500(300~700)	＜0.001
CD4⁺/L	He^［16］	461 (269~701)	645 (461~794)	184(103~293)	＜0.001
	Kong^［20］	400(200~600)	500(300~800)	200(100~400)	＜0.001
CD8⁺/L	He^［16］	291 (164~424)	366 (274~482)	121 (54~197)	＜0.001
	Kong^［20］	200(100~400)	300(200~500)	200(100~300)	＜0.001
CD4⁺/CD8⁺	He^［16］	1.66(1.27~2.20)	1.66 (1.37~2.16)	1.57(1.10~2.36)	0.342
	Kong^［20］	1.8(0.9~2.9)	0.2 (1~1.1)	1.5 (0.7-2.3)	0.030
CD19⁺/L	He^［16］	155 (105~229)	190 (139~268)	91 (54~139)	＜0.001
	Kong^［20］	100(100~200)	100(100~200)	100(50~100)	0.082
CD16⁺CD56⁺/L	He^［16］	127 (81~209)	144 (93~231)	105 (66~168)	＜0.001
	Kong^［20］	100(100~200)	200(100~300)	100(100~200)	0.074

指标	作者	总体	非重症	重症	P值
CD3⁺/L	He^［16］	801 (496~1154)	1 066(804~1321)	305(198~525)	＜0.001
	Kong^［20］	700(400~1000)	900(600~1300)	500(300~700)	＜0.001
CD4⁺/L	He^［16］	461 (269~701)	645 (461~794)	184(103~293)	＜0.001
	Kong^［20］	400(200~600)	500(300~800)	200(100~400)	＜0.001
CD8⁺/L	He^［16］	291 (164~424)	366 (274~482)	121 (54~197)	＜0.001
	Kong^［20］	200(100~400)	300(200~500)	200(100~300)	＜0.001
CD4⁺/CD8⁺	He^［16］	1.66(1.27~2.20)	1.66 (1.37~2.16)	1.57(1.10~2.36)	0.342
	Kong^［20］	1.8(0.9~2.9)	0.2 (1~1.1)	1.5 (0.7-2.3)	0.030
CD19⁺/L	He^［16］	155 (105~229)	190 (139~268)	91 (54~139)	＜0.001
	Kong^［20］	100(100~200)	100(100~200)	100(50~100)	0.082
CD16⁺CD56⁺/L	He^［16］	127 (81~209)	144 (93~231)	105 (66~168)	＜0.001
	Kong^［20］	100(100~200)	200(100~300)	100(100~200)	0.074

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