Based on the new era perspective of deepening curriculum construction in universities, improving curriculum quality has become an important task of the development of higher education and teaching. As the cradle of basic health talents training, it is increasingly urgent to construct a scientific and reasonable curriculum quality monitoring system in local medical colleges. This paper analyzes the problem existing in the curriculum quality monitoring system of colleges and universities, and combined with the characteristics of local medical colleges and actual work of Guangzhou Medical University, exploring and constructing a curriculum quality monitoring system integrating "diversified monitoring methods, full-dimension monitoring indicators, closed-loop feedback mechanism and multi-level cultural construction", and to provide practical references for similar institutions.