Mechanism of gut flora promoting Norovirus infection

doi:10.3877/cma.j.issn.2095-5820.2023.04.008

Abstract

Abstract:

Norovirus (NoV) is a major cause of epidemic and self-limiting acute gastroenteritis in adults and children, and is one of the main pathogens causing viral diarrhea. Since the virus is still unable to be cultured in vitro, murine Norovirus (MNV) infected mice and tissue culture models are mainly used to explore the infection mechanism and pathogenesis of MNV. Based on the research of MNV both domestically and internationally, it has been proposed that the interaction between NoV, host, and gut microbiota can affect the infectivity of the virus, including promoting or inhibiting infection of NoV. This article reviews and analyzes the mechanism of gut flora promoting norovirus infection and the immune response induced by gut flora in the intestine after norovirus infection, providing new perspectives and ideas for further research on the infection mechanism of norovirus.

Key words: Norovirus, gut flora, bile acid, histo-blood group antigens

Qingyao Du, Yingwen Cao, Jianxiong Lin, Run Hao, Jingmin Wang, Ruiquan Xu, Xiaoxia Kou. Mechanism of gut flora promoting Norovirus infection[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2023, 11(04): 241-244,255.

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