Non-invasive diagnosis of liver fibrosis and their combined diagnositic value

doi:10.3877/cma.j.issn.2095-5820.2014.04.006

Abstract

Abstract:

Liver fibrosis is the common life-threatening complication caused by chronic liver disease and hard to be cured，although its main mechanism has been known； its early diagnosis and intervention are extremely important. Liver biopsy，yet the “gold standard”，has not been accepted by doctors and patients because of a big risk of injury and potential complications and other defects.Therefore，increasing interest has been directed towards the identification of non-invasive tools in recent years. These non-invasive tools are mainly based on biomarkers and imageology. Beginning with a single index test，multiple-index combination tests have been proposed to improve the accuracy of the noninvasive diagnosis for liver fibrosis.Transientelastography，acoustic radiation force impulse and magnetic resonance elastography are main noninvasive diagnostic tools of imageology for liver fibrosis. In this paper，a brief introduction of these non-invasive methods is made to better understand them and provide help for research and clinical application；their diagnostic value and limitations are also discussed.

Key words: Liver fibrosis, Biomarker, Elasticity imaging techniques

Zhiqiang Sun, Yaping Tian. Non-invasive diagnosis of liver fibrosis and their combined diagnositic value[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2014, 02(04): 24-30.

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