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Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2014, Vol. 02 ›› Issue (04): 31-36. doi: 10.3877/cma.j.issn.2095-5820.2014.04.007

• Reviews • Previous Articles     Next Articles

Blood microRNAs as biomarkers for early diagnosis of Alzheimer's disease

Rui Guo1, Zhang Li1, Yuanying Qi1, Hui Ye1, Zhiming Lu1,()   

  1. 1.Department of Clinical Laboratory,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China
  • Received:2014-07-06 Online:2014-11-28 Published:2024-12-03
  • Contact: Zhiming Lu

Abstract:

Alzheimer's disease(AD)is a progressive neurodegeneration and the most common form of dementia,which is characterized by progressive memory impairment,cognitive decline,altered behavior and language deficit. The main pathological changes are deposition of senile plaque,and neurofibrillary tangles.Currently there is no effective treatment for AD,only some drugs can be used to delay the disease process. It is urgent to improve the early diagnosis of AD,and give more effective intervention and treatment at the early stage. MicroRNAs are highly conserved small non-coding RNAs that regulate gene expression at the post-transcriptional level.MicroRNAs play an important regulatory role in neuron formation,differentiation and synaptic shaping. Neuronal pathological changes and apoptosis are associated with the alterations of microRNAs network. In the development of AD,the type and amount of microRNAs are constantly changing,so we can analyze the expression profile of microRNAs to monitor the AD pathogenesis.MicroRNAs can be released into the body fluids through the blood-brain barrier,and not be easily degraded due to its two stem-loop structure.This makes the microRNAs is expected as a new biomarker for the early diagnosis of AD. This review summarized recent studies focus on aberrant microRNAs expression in AD brain and blood.

Key words: Alzheimer's disease, Biomarker, MicroRNAs

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