The distribution of six indicators including lymphocyte subsets in white blood cell reduction patients

doi:10.3877/cma.j.issn.2095-5820.2015.02.014

Abstract

Abstract:

Objective

To evaluate the distribution and clinical significance of 6 indicators including lymphocyte subsets in patients with white blood cell reduction.

Methods

One hundred and three patients with white blood cells reduction who were diagnosed between January 2013 and December 2014 were divided into two groups according to the results of bone marrow examination (hyperplasia degree of granulocyte system). Methods to retrospective analyze the characters of C reactive protein (CRP), lactate dehydrogenase (LDH), 50% complement hemolysis (CH50), complement C3 (C3), erythrocyte sedimentation rate (ESR) and lymphocyte subsets between two white blood cell reduction groups, and to evaluate their effectiveness on bone marrow biopsy for white blood cell reduction diagnosis.

Results

T lymphocytes, T helper lymphocytes and natural killer(NK) cells in the bone marrow examination positive groups [(62.42 ±3.21) %, (21.39 ±2.39) %, (22.94 ± 1.81) %] and negative groups [(72.00 ±3.97) %, (29.73 ± 4.02) %,(11.32 ± 0.38) %]，results were statistically significant differences (t=3.791, 3.268, 8.658. P<0.05 or P>0.001). CRP in bone marrow puncture positive group (P₅₀=14.70) was higher than negative group (P₅₀=4.25,U=7.008, P=0.03).

Conclusions

Results show reduction of T lymphocytes and T helper lymphocytes,increase of NK cells and high expression of CRP in white blood cell reduction patients with less active marrow myeloid hyperplasia, which has reference value for auxiliary judging white blood cell reduction patients with less active marrow myeloid hyperplasia.

Key words: Lymphocyte subsets, C reactive protein

Jingqin Huang, Shanshan Xu, Te Zheng, Fenyong Sun. The distribution of six indicators including lymphocyte subsets in white blood cell reduction patients[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2015, 03(02): 123-126.

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Figures/Tables 5

病因类型	骨髓穿刺
病因类型	阳性（例）	阴性（例）
造血系统疾病	13	0
癌症化疗后	2	17
慢性肝炎	3	18
系统性红斑狼疮	1	10
病毒感染	4	14
其他原因	0	21
合计	23	80

检测项目	阳性组（n=23）	阴性组(n=80)	检验值	P值
WBC计数（×10⁹/L， $\bar{x}$ ±s）	2.19±0.87	2.45±0.68	t=1.528	0.222
CH50（U/ml， $\bar{x}$ ±s）	40.38±6.2	33.24±13.17	t=2.079	0.135
C3（g/L， $\bar{x}$ ±s）	0.94±0.19	0.87±0.30	t=0.430	0.652
T淋巴细胞（%， $\bar{x}$ ±s）	62.42±3.21	72.00±3.97	t=3.791	0.029
Ts细胞（%， $\bar{x}$ ±s）	38.53±4.79	40.56±4.54	t=0.240	0.787
Th细胞（%， $\bar{x}$ ±s）	21.39±2.39	29.73±4.02	t=3.268	0.046
B淋巴细胞（%， $\bar{x}$ ±s）	14.24±4.54	14.32±5.91	t=0.526	0.594
NK细胞（%， $\bar{x}$ ±s）	22.94±1.81	11.32±0.38	t=8.658	0.001
CRP[mg/L,M(P₂₅～P₇₅)]	14.70(5.08～80.20)	4.25(1.30～26.83)	U=7.008	0.030
LDH[U/L,M(P₂₅～P₇₅)]	233.00(133.50～379.75)	273.50(136.50～375.50)	U=2.909	0.234
ESR[mm/1 h,M(P₂₅～P₇₅)]	30.00(19.25～43.00)	22.00(11.50～55.75)	U=0.942	0.624

检测项目	阳性组（n=23）	阴性组(n=80)	检验值	P值
WBC计数（×10⁹/L， $\bar{x}$ ±s）	2.19±0.87	2.45±0.68	t=1.528	0.222
CH50（U/ml， $\bar{x}$ ±s）	40.38±6.2	33.24±13.17	t=2.079	0.135
C3（g/L， $\bar{x}$ ±s）	0.94±0.19	0.87±0.30	t=0.430	0.652
T淋巴细胞（%， $\bar{x}$ ±s）	62.42±3.21	72.00±3.97	t=3.791	0.029
Ts细胞（%， $\bar{x}$ ±s）	38.53±4.79	40.56±4.54	t=0.240	0.787
Th细胞（%， $\bar{x}$ ±s）	21.39±2.39	29.73±4.02	t=3.268	0.046
B淋巴细胞（%， $\bar{x}$ ±s）	14.24±4.54	14.32±5.91	t=0.526	0.594
NK细胞（%， $\bar{x}$ ±s）	22.94±1.81	11.32±0.38	t=8.658	0.001
CRP[mg/L,M(P₂₅～P₇₅)]	14.70(5.08～80.20)	4.25(1.30～26.83)	U=7.008	0.030
LDH[U/L,M(P₂₅～P₇₅)]	233.00(133.50～379.75)	273.50(136.50～375.50)	U=2.909	0.234
ESR[mm/1 h,M(P₂₅～P₇₅)]	30.00(19.25～43.00)	22.00(11.50～55.75)	U=0.942	0.624

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