Analysize serum cholylglycine, total bile acid, alanine aminotransferase level of pregnancy intrahepatic cholestasis

doi:10.3877/cma.j.jssn.2095-5820.2016.01.012

Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2016, Vol. 04 ›› Issue (01): 54-56. doi: 10.3877/cma.j.jssn.2095-5820.2016.01.012

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Analysize serum cholylglycine, total bile acid, alanine aminotransferase level of pregnancy intrahepatic cholestasis

Lirong Han¹(), Mingchao Zhu¹, Dongyang Yu¹

Received:2016-02-02 Online:2016-02-28 Published:2016-02-28
Contact: Lirong Han

Abstract

Lirong Han, Mingchao Zhu, Dongyang Yu. Analysize serum cholylglycine, total bile acid, alanine aminotransferase level of pregnancy intrahepatic cholestasis[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2016, 04(01): 54-56.

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References 12

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3	余春风，鲁建央，王志华. 妊娠期肝内胆汁淤积症诊断标准的解读[J]. 全科医学临床与教育, 2014,12(5): 534-536.
4	林一，王厚照. 120例ICP患者血清中CG、TBA与TSH水平变化分析[J]. 中国优生与遗传杂志, 2014,22(11):128-129.
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12	谢彦玲，李晓勤，豆媛媛. 血清甘胆酸、谷丙转氨酶、总胆汁酸检测在妊娠期肝内胆汁淤积症临床诊断中的意义[J], 中国优生与遗传杂志, 2014,22(10):87.

组别	例数	CG (mg/L)	TBA (μmol/L)	ALT (U/L)
ICP组	62	51.2±12.3	37.4±6.1	195.8±92.3
健康对照组	80	2.3±0.8	8.3±1.0	29.6±9.4
t值	?	14.81	4.37	4.36
P值	?	<0.05	<0.05	<0.05

组别	例数	CG (mg/L)	TBA (μmol/L)	ALT (U/L)
ICP组	62	51.2±12.3	37.4±6.1	195.8±92.3
健康对照组	80	2.3±0.8	8.3±1.0	29.6±9.4
t值	?	14.81	4.37	4.36
P值	?	<0.05	<0.05	<0.05

组别	CG	TBA	ALT	(CG＋TBA )
ICP组	96.8(60/62)	75.8(47/62)	50.0(31/62)	93.5(58/62)
健康对照组	5.0( 4/80)	25.0(20/80	65.0(52/80)	2.5(2/80)
χ²值	18.88	56.71	0.92	14.50
P值	<0.001	<0.001	0.339	<0.001

组别	CG	TBA	ALT	(CG＋TBA )
ICP组	96.8(60/62)	75.8(47/62)	50.0(31/62)	93.5(58/62)
健康对照组	5.0( 4/80)	25.0(20/80	65.0(52/80)	2.5(2/80)
χ²值	18.88	56.71	0.92	14.50
P值	<0.001	<0.001	0.339	<0.001

临床特征	例数	ICP例数	ICP发生率(%)
年龄(岁)	?	?	?
20~25	20	1	5.0(1/20)
25~30	45	2	4.4(2/45)
30~34	11	2	18.2(2/11)
35~38	50	32	64.0(32/50)
38~42	16	9	75.0(9/16)
孕周(周)	?	?	?
16~22	17	1	5.9(1/17)
22~28	26	3	11.5(3/26)
28~35	68	44	64.7(44/68)
35~42	31	25	80.6(25/31)

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检测指标	敏感度	特异度	假阴性率	假阳性率	诊断准确度
CG	96.8(60/62)	95.0(76/80)	3.2(2/62)	5.0(4/80)	95.8(136/142)
TBA	75.8(47/62)	75.0(60/80)	24.2(15/62)	25.0(20/80)	75.4(107/142)
ALT	50.0(31/62)	35.0(28/80)	50.0(31/62)	65.0(52/80)	41.5(59/142)
CG＋TBA	93.5(58/62)	97.5(78/80)	6.5(4/62)	2.5(2/80)	95.8(136/142)

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