Comparison of blood concentration monitoring of Cyclosporine A in bone marrow transplant patients by two methods

doi:10.3877/cma.j.issn.2095-5820.2017.04.010

Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2017, Vol. 05 ›› Issue (04): 240-244. doi: 10.3877/cma.j.issn.2095-5820.2017.04.010

Special Issue: ；

• Clinical Research • Previous Articles Next Articles

Comparison of blood concentration monitoring of Cyclosporine A in bone marrow transplant patients by two methods

Lei Wang¹, Hongchun Wang¹, Peiyu Li¹, Wenli Sun¹, Hongxing Liu¹^,^†()

^1. Department of Clinical Pharmacology, Hebei Yanda Ludaopei Hospital, Sanhe 065201, China

Received:2017-07-25 Online:2017-11-28 Published:2017-11-28
Contact: Hongxing Liu
About author:
Corresponding author: Liu Hongxing, Email: lhongxing@outlook.com

Abstract

Abstract:

Objective

To discuss the correlation of chemiluminescence microparticle immunoassays and Elecsys for the determination of blood concentration of cyclosporine A (CSA) in bone marrow transplant patients, providing the basis for the adjustment of clinical medication regime.

Methods

Whole blood samples of 83 patients underwent bone marrow transplant were randomly collected and determined by CMIA and Elecsys respectively. The difference and correlation of 2 kinds of determination methods were investigated.

Results

The linear correlation of CMIA and Elecsys results was good and the regression equation was Y=1.4618X-2.2309 (r=0.9105). CSA determination results by CMIA (195.75 ng/ml)>Elecsys(135.44 ng/ml); CSA mean best estimate by CMIA (181.97 ng/ml) and Elecsys(117.49 ng/ml); The results of the two methods are logarithmic normal distribution, and the conversion coefficient is 1.55. According to the clinical reference range (150-250 ng/ml) of CMIA method of bone marrow transplant patients, the clinical reference range of Elecsys was 100-200 ng/ml.

Conclusions

Both methods are feasible for blood concentration monitoring of CSA but there are difference in determination result. Great importance should be paid to CSA monitoring method reference interval in the adjustment of medication method in the clinic.

Key words: Elecsys, Chemiluminescence microparticle immunoassays, Cyclosporin A, Drug concentration

Lei Wang, Hongchun Wang, Peiyu Li, Wenli Sun, Hongxing Liu. Comparison of blood concentration monitoring of Cyclosporine A in bone marrow transplant patients by two methods[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2017, 05(04): 240-244.

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