Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2019, Vol. 07 ›› Issue (04): 214-218. doi: 10.3877/cma.j.issn.2095-5820.2019.04.006

Special Issue:

• Clinical Research • Previous Articles     Next Articles

Study on the diagnostic value of serum pepsinogen and gastrin-17 in gastric cancer and atrophic gastritis

Yunfei An1, Fei Ding1, Bei Cai1, Wenling Zhao1, Jing Hu1, Zhuochun Huang1, Lixin Li1,()   

  1. 1. Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
  • Received:2018-08-02 Online:2019-11-28 Published:2019-11-28
  • Contact: Lixin Li
  • About author:
    Corresponding author: Li Lixin, Email:

Abstract:

Objective

To investigate the level changes and clinical value of serum pepsinogen (PG) and gastrin-17 (Gastrin-17) in non-atrophic gastritis, atrophic gastritis and gastric cancer.

Method

Pepsinogen Ⅰ (PGⅠ), pepsinogen Ⅱ (PGⅡ), gastrin-17 (G-17) and the PGⅠ/PGⅡ (PGR) levels were measured in 37 patients with non-atrophic gastritis, 37 patients with atrophic gastritis and 65 patients with gastric cancer by enzyme-linked immunosorbent assay.

Results

The PGⅠand PGR in the atrophic gastritis group were significantly lower than those in the non-atrophic gastritis group (P<0.05). The PGⅠand PGR levels in the gastric cancer group were significantly lower than those in non-atrophic gastritis group and atrophic gastritis group (P<0.05). The level of PGⅡ in the gastric cancer group was significantly higher than that in the non-atrophic gastritis group (P<0.05). The G-17 in the gastric cancer group was significantly higher than that that in the atrophic gastritis and non-atrophic gastritis group (P<0.05). The G-17 in the gastric antrum cancer group was significantly higher than that in the gastric body cancer group (P<0.05).

Conclusions

Pepsinogen and gastrin can be used as serological markers for screening atrophic gastritis and gastric cancer. Serum gastrin-17 has great clinical value in distinguishing gastric antrum and gastric body cancer.

Key words: Pepsinogen, Stomach neoplasms, Atrophic gastritis, Gastrin-17

京ICP 备07035254号-20
Copyright © Chinese Journal of Clinical Laboratory Management(Electronic Edition), All Rights Reserved.
Tel: 020-81341720 Fax: 020-37103505 E-mail: clinlab@cma.org.cn
Powered by Beijing Magtech Co. Ltd