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Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2021, Vol. 09 ›› Issue (02): 99-104. doi: 10.3877/cma.j.issn.2095-5820.2021.02.008

Special Issue:

• Big Data Analysis • Previous Articles     Next Articles

Multi-database analysis of HELQ expression in renal clear cell carcinoma and its clinical application value

Xiaohui He1, Fang Luo2, Hailong Wang3, Zhaoting Liu2,()   

  1. 1. Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou Guangdong 510515, China; School of life science and technology, Shanghaitech University, Shanghai 201210, China
    2. Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou Guangdong 510515, China
    3. Kingmed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou Guangdong 510182, China
  • Received:2020-12-17 Online:2021-05-28 Published:2021-06-28
  • Contact: Zhaoting Liu

Abstract:

Objective

To investigate the expression of HELQ and homologous reconbination pathway related genes in renal clear cell carcinoma (ccRCC) and the effect on patients' survival.

Methods

Expression of HELQ mRNA in ccRCC and normal samples were determined by websites of GEPIA and UALCAN. R2 website was used to analyze the relationship between the expression of HELQ mRNA and the grade of renal clear cell carcinoma. The relationship between HELQ mRNA expression and TNM staging was investigated by LinkedOmics and R2. We also used UALCAN, Kaplan-Meier Plotter, OncoLnc to detect the expression of HELQ mRNA on ccRCC patients' survival. Finally, we explored the expression of genes in homologous recombination pathway on ccRCC patients' survival. R2 website was used to analyze the survival effect of homologous recombination pathway related genes on patients with renal clear cell carcinoma.

Results

Compared to normal renal tissues, expression of HELQ was lower in clear cell renal cell carcinoma (P<0.01). Expression of HELQ tended to decrease with grades (P<0.01) and the stages of renal clear cell cell carcinoma. Besides patients with lymphatic metastasis and distant metastasis had lower HELQ mRNA expression (P<0.01). Expression of HELQ was positively correlated with patients' survival (P<0.01). The expression of 21 genes in homologous recombination pathway also influenced ccRCC patients' survival.

Conclusion

HELQ may have relationship with the development of renal clear cell cell carcinoma.

Key words: HELQ, Clear cell renal cell carcinoma, Prognosis, Website analysis

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