Abstract:

Objective

To investigate the clinical infection status of ureaplasma urealyticum (UU),mycoplasma hominis (MH) and chlamydia trachomatis (CT) in the genital tract of female infertility patients in Guangzhou area.

Methods

505 cases of female infertility patients in outpatient clinics of Guangdong Women and Children Hospital were selected, including 215 cases of primary infertility patients (primary infertility group) and 290 cases of secondary infertility patients (secondary infertility group), and 60 cases of normal pregnancy and obstetrics examination in Guangdong Women and Children Hospital in the same period of time were taken as the control group, and all of the patients were tested for CT antigen and the cultivation of UU and MH, as well as drug sensitivity test.

Results

The positive rates of single infections of UU, MH and CT in patients in the infertility group were 46.1%, 8.5% and 6.5%, respectively, which were significantly higher than those in the control group (P＜0.05); the positive rate of single infections in patients in the infertility group was 61.2% (309/505), and that of mixed infections was 11.9% (60/505), and there was no statistical significance in the difference of positive rates of mixed infections when compared with those in the control group (P＞0.05). The positive rates of UU, MH and CT single infections and mixed infections were similar in the primary and secondary infertility groups, and there was no statistically significant difference in the positive rates of single infections and mixed infections between the two groups (P＞0.05); UU and UU+MH mixed infections were both more sensitive to doxycycline and cosyntropin; the difference in the positive rate of UU was statistically significant in patients of different ages (P＜0.05), with the highest UU positivity rate in women in the ≥41-year-old group, and the differences in MH and CT positivity rates were not statistically significant in all age groups (P＞0.05)

Conclusion

Positive rates of female genital tract UU, MH, and CT infections are positively correlated with the occurrence of infertility, and female patients with all types of infertility should be intensely screened for these pathogens.

Key words: infertility, ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis