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中华临床实验室管理电子杂志 ›› 2014, Vol. 02 ›› Issue (04) : 37 -40. doi: 10.3877/cma.j.issn.2095-5820.2014.04.008

综述

载脂蛋白与脓毒症的关系
杜文涵1, 胡敏1,()   
  1. 1.410011 长沙,中南大学湘雅医学院二院检验科
  • 收稿日期:2014-08-06 出版日期:2014-11-28
  • 通信作者: 胡敏

Apolipoprotein and sepsis

Wenhan Du1, Min Hu1,()   

  1. 1.Department of Clinical Laboratory,the Sencond Xiangya Hospital,Central South University,Changsha 410011,China
  • Received:2014-08-06 Published:2014-11-28
  • Corresponding author: Min Hu
引用本文:

杜文涵, 胡敏. 载脂蛋白与脓毒症的关系[J/OL]. 中华临床实验室管理电子杂志, 2014, 02(04): 37-40.

Wenhan Du, Min Hu. Apolipoprotein and sepsis[J/OL]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2014, 02(04): 37-40.

脓毒症是一种严重感染引起的全身炎症反应,具有高发病率和高病死率的特点,是现代危重病学面临的十分复杂的问题。 载脂蛋白(apolipoprotein,APO)是结合脂蛋白质,其主要功能是修饰并影响与脂蛋白代谢有关的酶的活性,同时作为脂蛋白受体配体,参与脂蛋白代谢。 近年许多研究发现,多种载脂蛋白,如apoA-I,apoC-I能够结合脂多糖(lipopolysaccharide,LPS),减弱炎症反应,起到保护机体的作用。 在此,对APO在脓毒症中的作用予以综述,并阐述其未来研究方向。

Sepsis is a systemic inflammatory response caused by serious infection.Due to its high morbidity and mortality,sepsis is a widespread and complex issue in modern critical care.Apolipoproteins(APO)are proteins bound to lipids,their main functions are to modify and influence the activity of the enzymes related to lipoprotein metabolism,meanwhile,APO act as lipoprotein receptor ligands involved in lipoprotein metabolism. In recent years,increasing evidences indicated that a variety of apolipoproteins such as apolipoprotein(apoA-I),apoC-I can bind lipoplysacchanvide(LPS),attenuate inflammatory response,and protect the host.This report reviewed the potential functions of APO in sepsis and its further research.

1
Martin GS,Mannino DM,Eaton S,et al. The Epidemiology of sepsis in the United States from 1979 through 2000 [J]. N Engl J Med,2003,348(16):1546-1554.
2
Ma J,Liao XL,Luo B,et al. Role of apolipoprotein A-I in protecting against endotoxin toxicity[J]. Acta Biochim Biophys Sinica,2004,36(6):419-424.
3
Gupta H,Dai L,Datta G,et al. Inhibition of lipopolysaccharideinduced inflammatory responses by an apolipoprotein AI mimetic peptide[J].Circ Res,2005,97(3):236-243.
4
Henning MF,Herlax V,Bakas L. Contribution of the C-terminal end of apolipoprotein AI to neutralization of lipopolysaccharide endotoxic effect[J].Innate Immun,2011,17(3):327-337.
5
Li Y,Dong JB,Wu MP. Human ApoA-Ⅰ overexpression diminishes LPS-induced systemic inflammation and multiple organ damage in mice[J].Eur J Pharmacol,2008,590(1-3):417-422.
6
Yan Y,Li Y,Lou B,et al. Beneficial effects of ApoA-Ⅰ on LPSinduced acute lung injury and endotoxemia in mice[J]. Life Sci,2006,79(2):210-215.
7
Wang L,Chen WZ,Wu MP.Apolipoprotein A-I inhibits chemotaxis,adhesion,activation of THP-l cells and improves the plasma HDL inflammatory index[J].Cytokine,2010,49(2):194-200.
8
Barlage S,Frohlich D,Bottcher A,et al. ApoE-containing high density lipoproteins and phospholipid transferprotein activity increase in patients with a systemic inflammatory response[J]. J Lipid Res,2001,42(2):281-290.
9
Berbée JF,vander Hoogt CC,Kleemann R,et al.Apolipoprotein C-I stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis[J].FASEB J,2006,20(12):2162-2164.
10
Berbée JF,van der Hoogt CC,Sundararaman D,et al. Severe hypertriglyceridemia in human APOC-I transgenic mice is caused by apoC-I-induced inhibition of LPL [J]. J Lipid Res,2005,46(2):2 9 7-3 0 4.
11
Conde-Knape K,Bensadoun A,Sobel JH,et al. Overexpression of apoC-I in apoE-null mice: severe hypertriglyceridemia due to inhibition of hepatic lipase[J].J Lipid Res,2002,43(12):2136-2145.
12
Shachter NS. Apolipoproteins C-I and C-Ⅲ as important modulators of lipoprotein metabolism[J].Curr Opin Lipidol,2001,12(3):297-304.
13
Berbée JF,Coomans CP,Westerterp M,et al. Apolipoprotein CI enhances the biological response to LPS via the CD14/TLR4 pathway by LPS-binding elements in both its N-and C-terminal helix[J]. J Lipid Res,2010,51(7):1943-1952.
14
Fu P,Wang AM,He LY,et al. Elevated serum ApoE levels are associated with bacterial infections in pediatric patients[J].J Microbiol Immunol Infect,2014,47(2):122-129.
15
Li L,Thompson PA,Kitchens RL. Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene:role of hepatic LDL receptors[J]. 2008,J Lipid Res,2008,49(8):1 7 8 2-1 7 9 3.
16
Wang C,Wang Y,Wang A,et al.The diagnostic value of apolipoprotein E in pediatric patients with invasive bacterial infections[J]. Clin Biochem,2012,45(3):215-218.
17
Zhang HL,Wu LM,Wu J. Cross-talk between Apolipoprotein E and cytokines[J].Mediators Inflamm,2011,2011:949072.
18
Kattan OM,Kasravi FB,Elford EL,et al. Apolipoprotein E-mediated immune regulation in sepsis[J].Immunology,2008,181(2):1399-1408.
19
van den Elzen P,Garg S,Leon L,et al. Apolipoprotein-mediated pathways of lipid antigen presentation[J]. Nature,2005,437(7060):9 0 6-91 0.
20
Kelley I. Chuang,Briana Leung,Nancy Hsu,et al. Heparin protects against septic mortality via apoE-antagonism[J]. American J Surg,2011,202(3):325-335.
21
Kumaraswamy SB,Linder A,Akesson P,et al. Decreased plasma concentrations of apolipoprotein M in sepsis and systemic inflammatory response syndromes[J]. Crit Care,2012,16(2):11 93-1 2 0 3.
22
石岩.严重脓毒症发病机制新认识[J].中国实用外科杂志,2012,32(11):956-958.
23
张柳,安友仲.中国危重病急救医学[J].2011,23(8):509-511.
24
Gräler MH. The role of sphingosine 1-phosphate in immunity and sepsis[J].Am J Clin Exp Immunol,2012,1(2):90-100.
25
Obinata H,Hla T. Sphingosine 1-phosphate in coagulation and inflammation[J].Semin Immunopathol[J].2012,34(1):73-91.
26
Camerer E,Regard JB,Cornelissen I,et al. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice[J].J Clin Invest,2009,119(7):1871-1879.
27
Sanchez T,Skoura A,Wu MT,et al.Timothy Hlalnduction of vascular permeability by the sphingosine-l-phosphate receptor-2 (S1P2R)and its downstream effectors ROCK and PTEN[J]. Arterioscler Thromb Vasc Biol,2007,27(6):1312-1318.
28
Sammani S,Moreno-Vinasco L,Mirzapoiazova T,et al. Differential effects of SIP receptors on airway and vascular barrier function in the murine lung[J].Am J Respir Cell Mol Biol,2010,43(4):394-402.
29
Zhang G,Xu S,Qian Y,et al. Sphingosine-l-phosphate prevents permeability increases via activation of endothelial sphingosinel-phosphate receptor 1 in rat venules[J]. Am J Physiol Heart Circ Physiol,2010,299(5):H1494-1504.
30
Singleton PA,Moreno-Vinasco L,Sammani S,et al.Attenuation of vascular permeability by methylaltrexone role of mOP-R and S 1 P3 transactivation[J]. Am J Respirat Cell Mol Biol[J]. 2007,37(2):2 2 2-2 3 1.
31
Shikata Y,Birukov KG,Garcia JG. SIP induces FA remodeling in human pulmonary endothelial cells: role of Rac,GIT1,FAK,and paxillin[J].JAppl Physiol(1985),2003,94(3):1193-1203.
32
Blaho VA,Hla T.Regulation of mammalian physiology,development,and disease by the sphingosine l-phosphate and lysophosphatidic acid receptors[J].Chem Rev,2011,111(10):6299-6320.
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