切换至 "中华医学电子期刊资源库"

中华临床实验室管理电子杂志 ›› 2015, Vol. 03 ›› Issue (04) : 217 -220. doi: 10.3877/cma.j.issn.2095-5820.2015.04.006

所属专题: 文献

综述

女性抗苗勒管激素的临床应用新进展
岳朝艳, 应春妹   
  • 收稿日期:2015-09-17 出版日期:2015-11-28
  • 通信作者: 应春妹

Recent advances in the clinical applications of female anti-Müllerian hormone

Chaoyan Yue, Chunmei Ying   

  • Received:2015-09-17 Published:2015-11-28
  • Corresponding author: Chunmei Ying
  • About author:
    Corresponding author: Ying Chunmei. Email:
引用本文:

岳朝艳, 应春妹. 女性抗苗勒管激素的临床应用新进展[J/OL]. 中华临床实验室管理电子杂志, 2015, 03(04): 217-220.

Chaoyan Yue, Chunmei Ying. Recent advances in the clinical applications of female anti-Müllerian hormone[J/OL]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2015, 03(04): 217-220.

女性抗苗勒管激素(anti-Müllerrian hormone, AMH)来源于卵泡发育早期的卵泡颗粒细胞,在卵泡成熟调控中起重要的作用。AMH是目前评估卵巢储备功能以及多囊卵巢综合症的诊断与跟踪指标之一;也可作为某些卵巢肿瘤的诊断、疗效评估和复发监测的肿瘤标志。在辅助生殖领域,AMH测定有助于卵巢超刺激的个性化给药,从而提高体外受精(in vitro fertilization, IVF)的效率和安全性。AMH在临床上的广泛应用,有助于为个性化、合理化的治疗方案提供参考。

Female anti-Müllerian hormone(AMH) is derived from the early follicular granulosa cells, which plays an important role in the regulation of follicular maturation. AMH is one of the indicators of the diagnosis and tracking of ovarian reserve function and polycystic ovary syndrome (PCOS), and also can be used as a tumor marker in the diagnosis, treatment and recurrence of ovarian tumors. In the field of assisted reproduction, AMH assay is helpful to the individualized administration of ovarian hyper stimulation to improve the efficiency and safety of in vitro fertilization (IVF). The wide application of AMH in clinical practice is helpful to provide a reference for the individualized and rational treatment.

[1]
Wilson JD, George FW, Griffin JE. The hormonal control of sexual development[J]. Science, 1981, 211(4488):1278–1284.
[2]
Teixeira J, Maheswaran S, Donahoe PK. Mullerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications[J]. Endocr Rev, 2001, 22(5):657–674.
[3]
Salhi I, Cambon-Roques S, Lamarre I, et al. The anti-Mullerian hormone type II receptor: insights into the binding domains recognized by a monoclonal antibody and the natural ligand[J]. Biochem J, 2004, 379(Pt 3):785–793.
[4]
de Vet A, Laven JSE, de Jong FH, et al. Anti-Mullerian Hormone serum levels: A putative marker for ovarian aging[J]. Fertil Steril, 2002, 77(2):357–362.
[5]
Hansen KR, Hodnett GM, Knowlton N, et al. Correlation of ovarian reserve tests with histologically determined primordial follicle number[J]. Fertil Steril, 2011, 95(1):170–175.
[6]
Hagen CP, Aksglaede L, Sorensen K, et al. Serum levels of anti-Mullerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients[J]. J Clin Endocrinol Metab, 2010, 95(11):5003–5010.
[7]
Kelsey TW, Wright P, Nelson SM, et al. A validated model of serum anti-mullerian hormone from conception to menopause[J]. PLoS One, 2011, 6(7):e22024.
[8]
Lie Fong S, Visser JA, Welt CK, et al. Serum anti-mullerian hormone levels in healthy females: a nomogram ranging from infancy to adulthood[J]. J Clin Endocrinol Metab, 2012, 97(12):4650–4655.
[9]
teVelde ER, Pearson PL. The variability of female reproductive ageing[J]. Hum Reprod Update, 2002, 8(2):141–154.
[10]
Broekmans FJ, Soules MR, Fauser BC. Ovarian aging: mechanisms and clinical consequences[J]. Endocr Rev, 2009, 30(5):465–493.
[11]
Broer SL, Eijkemans MJ, Scheffer GJ, et al. Anti-mullerian hormone predicts menopause: along-term follow-up study in normoovulatorywomen[J]. J Clin Endocrinol Metab, 2011, 96(8):2532–2539.
[12]
Freeman EW, Sammel MD, Lin H, Gracia CR. Anti-mullerian hormone as a predictor of time to menopause in late reproductive age women[J]. J Clin Endocrinol Metab, 2012, 97(5):1673–1680.
[13]
Dolleman M, Faddy MJ, van Disseldorp J, et al. The relationship between anti-Mullerian hormone in women receiving fertility assessments and age at menopause in subfertile women: evidence from large population studies[J]. J Clin Endocrinol Metab, 2013a 98(5):1946–1953.
[14]
Dewailly D, Gronier H, Poncelet E, et al. Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries[J]. Hum Reprod, 2011, 26(11):3123–3129.
[15]
Dewailly D, Lujan ME, Carmina E, et al. Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society[J]. Hum Reprod Update, 2014, 20(3):334–352.
[16]
Eilertsen TB, Vanky E, Carlsen SM. Anti-Mullerian hormone in the diagnosis of polycystic ovary syndrome: can morphologic description be replaced?[J]. Hum Reprod, 2012, 27(8):2494–2502.
[17]
Laven JS, Mulders AG, Visser JA, et al. Anti-Mullerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age[J]. J Clin Endocrinol Metab, 2004, 89(1):318–323.
[18]
Piouka A, Farmakiotis D, Katsikis I, et al. Anti-Mullerian hormone levels reflect severity of PCOS but are negatively influenced by obesity: relationship with increased luteinizing hormone levels[J]. Am J Physiol Endocrinol Metab, 2009, 29–6(2):E238–E243.
[19]
Iliodromiti S, Kelsey TW, Anderson RA, et al. Can anti-mullerian hormone predict the diagnosis of polycystic ovary syndrome? A systematic review and meta-analysis of extracted data[J]. J Clin Endocrinol Metab, 2013, 98(8):3332–3340.
[20]
Baker VL. Primary ovarian insufficiency in the adolescent[J]. Curr Opin Obstet Gynecol, 2013, 25(5):375–381.
[21]
Leader B, Bakerb VL. Maximizing the clinical utility of antimullerian hormone testing in women’s health[J]. Curr Opin Obstet Gynecol, 2014, 26(4):226–236.
[22]
Lane AH, Lee MM, Fuller AF Jr, et al. Diagnostic utility of Mullerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors[J]. Gynecol Oncol, 1999, 73(1):51–55.
[23]
Mancaux A, GrardelChambenoit E, Gagneur O, et al. Granulosa cell tumor: difficulty of diagnosis and contribution of imaging[J]. Gynecol Obstet Fertil, 2013, 41(7–8):439–445.
[24]
Ha TU, Segev DL, Barbie D, et al. Mullerian inhibiting substance inhibits ovarian cell growth through an Rb-independent mechanism[J]. J Biol Chem, 2000, 275(47):37101–37109.
[25]
Stephen AE, Pearsall LA, Christian BP, et al. Highly purified mullerian inhibiting substance inhibits human ovarian cancer in vivo. Clin Cancer Res, 2002, 8(8):2640–2646.
[26]
Berkenblit A, Cannistra SA. Advances in the management of epithelial ovarian cancer[J]. J Reprod Med, 2005, 50(6):426–438.
[27]
Renaud EJ, MacLaughlin DT, Oliva E, et al. Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance[J]. Proc Natl Acad Sci, 2005, 102(1):111–116.
[28]
Kim JH, MacLaughlin DT, Donahoe PK. Müllerian inhibiting substance/anti-Müllerian hormone: A novel treatment for gynecologic tumors[J]. Obstet Gynecol Sci, 2014, 57(5):343–357.
[29]
Yates AP, Rustamov O, Roberts SA, et al. Anti-Mullerian hormone-tailored stimulation protocols improve outcomes whilst reducing adverse effects and costs of IVF[J]. Hum Reprod, 2011, 26(9):2353–2362.
[30]
La Marca A, Papaleo E, Grisendi V, et al. Development of a nomogram based on markers of ovarian reserve for the individualisation of the follicle-stimulating hormone starting dose in vitro fertilisation cycles[J]. BJOG, 2012, 119(10):1171–1179.
[31]
Broer SL, van DJ, Broeze KA, et al. Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach[J]. Hum Reprod Update, 2013b 19(1):26–36.
[32]
Arce JC, La MA, Mirner KB, et al. Antimullerian hormone in gonadotropin releasing-hormone antagonist cycles: prediction of ovarian response and cumulative treatment outcome in good-prognosis patients[J]. Fertil Steril, 2013, 99(6):1644–1653.
[33]
Brodin T, Hadziosmanovic N, Berglund L, et al. Antimullerian hormone levels are strongly associated with live-birth rates after assisted reproduction[J]. J Clin Endocrinol Metab, 2013, 98(3):1107–1114.
[34]
La Marca A, Nelson SM, Sighinolfi G, et al. Anti-Mullerian hormone-based prediction model for a live birth in assisted reproduction[J]. Reprod Biomed Online, 2011, 22(4):341–349.
[35]
Namkung J, Song JY, Jo HH, et al. Mullerian inhibiting substance induces apoptosis of human endometrial stromal cells in endometriosis[J]. J Clin Endocrinol Metab, 2012, 97(9):3224–3230.
[36]
Borahay MA, Lu F, Ozpolat B, et al. Mullerian inhibiting substance suppresses proliferation and induces apoptosis and autophagy in endometriosis cells in vitro[J]. ISRN Obstet Gynecol, 2013, 2013:361489.
[37]
Fabregues F, Castelo-Branco C, Carmona F, et al. The effect of differentvhormone therapies on antimullerian hormone serum levels in anovulatoryvwomen of reproductive age[J]. Gynecol Endocrinol, 2011, 27(4):216–224.
[38]
Mes-Krowinkel MG, Louwers YV, Mulders AG, et al. Influence of oral contraceptivesvonanthropomorphometric, endocrine, and metabolic profiles ofvanovulatory polycystic ovary syndrome patients[J]. Fertil Steril, 2014, 101(6):1757–1765.
[39]
Broer SL, Broekmans FJ, Laven JS, et al. Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications[J]. Hum Reprod Update, 2014, 20(5):688–701.
[40]
Dolleman M, Verschuren WM, Eijkemans MJ, et al. Reproductive and lifestyle determinants of anti-Mullerian hormone in a large population-based study[J]. J Clin Endocrinol Metab, 2013b 98(5):2106–2115.
[1] 李国新, 陈新华. 全腹腔镜下全胃切除术食管空肠吻合的临床研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 1-4.
[2] 陈方鹏, 杨大伟, 金从稳. 腹腔镜近端胃癌切除术联合改良食管胃吻合术重建His角对术后反流性食管炎的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 15-18.
[3] 许杰, 李亚俊, 韩军伟. 两种入路下腹腔镜根治性全胃切除术治疗超重胃癌的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 19-22.
[4] 李刘庆, 陈小翔, 吕成余. 全腹腔镜与腹腔镜辅助远端胃癌根治术治疗进展期胃癌的近中期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 23-26.
[5] 刘世君, 马杰, 师鲁静. 胃癌完整系膜切除术+标准D2根治术治疗进展期胃癌的近中期随访研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 27-30.
[6] 任佳, 马胜辉, 王馨, 石秀霞, 蔡淑云. 腹腔镜全胃切除、间置空肠代胃术的临床观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 31-34.
[7] 赵丽霞, 王春霞, 陈一锋, 胡东平, 张维胜, 王涛, 张洪来. 内脏型肥胖对腹腔镜直肠癌根治术后早期并发症的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 35-39.
[8] 吴晖, 佴永军, 施雪松, 魏晓为. 两种解剖入路下行直肠癌侧方淋巴结清扫的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 40-43.
[9] 周世振, 朱兴亚, 袁庆港, 刘理想, 王凯, 缪骥, 丁超, 汪灏, 管文贤. 吲哚菁绿荧光成像技术在腹腔镜直肠癌侧方淋巴结清扫中的应用效果分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 44-47.
[10] 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59.
[11] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[12] 徐逸男. 不同术式治疗梗阻性左半结直肠癌的疗效观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 72-75.
[13] 王露, 周丽君. 全腹腔镜下远端胃大部切除不同吻合方式对胃癌患者胃功能恢复、并发症发生率的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 92-95.
[14] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
[15] 陈浩, 王萌. 胃印戒细胞癌的临床病理特征及治疗选择的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 108-111.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?