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中华临床实验室管理电子杂志 ›› 2020, Vol. 08 ›› Issue (03) : 129 -132. doi: 10.3877/cma.j.issn.2095-5820.2020.03.001

所属专题: 文献

综述

吡咯啉-5-羧酸还原酶-1在恶性肿瘤中的研究进展
张丽红1,(), 王超超2   
  1. 1. 312000 浙江绍兴,绍兴市人民医院临床检验中心
    2. 325000 浙江温州,温州医科大学
  • 收稿日期:2020-06-02 出版日期:2020-08-28
  • 通信作者: 张丽红
  • 基金资助:
    浙江省基础公益研究计划项目(LGF19H200004); 浙江省医药卫生科技面上项目(2020KY326); 绍兴市科技计划项目(2018C30057)

Research progress of pyrroline-5-carboxylic acid reductase-1 in malignant tumor

Lihong Zhang1,(), Chaochao Wang2   

  1. 1. Shaoxing People's Hospital, Shaoxing Zhejiang 312000, China
    2. Wenzhou Medical University, Wenzhou Zhejiang 325000, China
  • Received:2020-06-02 Published:2020-08-28
  • Corresponding author: Lihong Zhang
  • About author:
    Corresponding author: Zhang Lihong, E-mail:
引用本文:

张丽红, 王超超. 吡咯啉-5-羧酸还原酶-1在恶性肿瘤中的研究进展[J/OL]. 中华临床实验室管理电子杂志, 2020, 08(03): 129-132.

Lihong Zhang, Chaochao Wang. Research progress of pyrroline-5-carboxylic acid reductase-1 in malignant tumor[J/OL]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2020, 08(03): 129-132.

吡咯啉-5-羧酸还原酶-1(Pyrroline-5-Carboxylate Reductase-1, PYCR1)是一种线粒体酶,其基因突变可导致人类皮肤松弛症。近年研究证明PYCR1能通过影响脯氨酸代谢发挥促进肿瘤生长增殖的作用。PYCR1在多种恶性肿瘤中高表达,且其表达水平与患者预后负相关。因此,PYCR1可能可以作为一种新型标志物,应用于肿瘤的诊断和预后,并有望成为肿瘤治疗的新靶点。

Pyrroline-5-carboxylate Reductase-1 (PYCR1) is a kind of mitochondrial enzyme, and its gene mutation could lead to human skin relaxation. Recent studies have shown that PYCR1 could promote tumor growth and proliferation by affecting praline metabolism. PYCR1 was highly expressed in several kinds of cancers, and the level of expression of PYCR1 was negatively related to the prognosis of patients.Therefore, PYCR1 may be used as a new marker in the diagnosis and prognosis of tumor, and may become a new target of tumor treatment.

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