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中华临床实验室管理电子杂志 ›› 2020, Vol. 08 ›› Issue (03) : 133 -139. doi: 10.3877/cma.j.issn.2095-5820.2020.03.002

所属专题: 文献

综述

EDTA依赖性假性血小板减少症的探析及其对策
廖远泉1,(), 郭喜1   
  1. 1. 242500 安徽泾县,安徽省泾县医院 检验科
  • 收稿日期:2020-04-26 出版日期:2020-08-28
  • 通信作者: 廖远泉

Analysis and countermeasures of EDTA-dependent pseudo thrombocytopenia

Yuanquan Liao1,(), Xi Guo1   

  1. 1. Department of Clinical laboratory, Anhui Jingxian People's Hospital, Jingxian Anhui 242500, China
  • Received:2020-04-26 Published:2020-08-28
  • Corresponding author: Yuanquan Liao
  • About author:
    Corresponding author: Liao Yuanquan, E-mail:
引用本文:

廖远泉, 郭喜. EDTA依赖性假性血小板减少症的探析及其对策[J]. 中华临床实验室管理电子杂志, 2020, 08(03): 133-139.

Yuanquan Liao, Xi Guo. Analysis and countermeasures of EDTA-dependent pseudo thrombocytopenia[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2020, 08(03): 133-139.

血液分析仪采用抗凝剂EDTA-K2抗凝进行血液细胞分析时,有时会发生血小板聚集,导致血小板计数出现假性偏低的现象,即EDTA依赖性假性血小板减少症(EDTA-dependent pseudo thrombocytopenia, EDTA-PTCP)。EDTA-PTCP如未被及时发现,会给患者的临床诊断和治疗造成误诊、误治,甚至会引起医疗纠纷。因此,对EDTA-PTCP相关因素的探析及其实验室对策的研究备受关注,尤其是EDTA-PTCP实验室解决方案的建立更有必要。文章探析了血液细胞分析仪因EDTA导致的EDTA-PTCP发生的相关因素,论述了相应的解决方案及其实验室质量控制。

When the blood analyzer uses the anticoagulant EDTA-K2 anticoagulant for blood cell analysis, sometimes platelet aggregation, resulting in a pseudo-low platelet count phenomenon, that is, EDTA-dependent pseudo thrombocytopenia (EDTA-dependent pseudo thrombocytopenia , EDTA-PTCP). If EDTA-PTCP was not discovered in time, it may cause misdiagnosis and even medical disputes in patients' clinical diagnosis and treatment. Therefore, the analysis of EDTA-PTCP related factors and the research of laboratory countermeasures have attracted much attention, especially the establishment of EDTA-PTCP laboratory solutions is more necessary. This article explores the factors related to the occurrence of EDTA-PTCP caused by EDTA in blood cell analyzers, and discusses the corresponding solutions and laboratory quality control.

图1 白细胞和血小板直方图:异常(a)(b)/正常(c)(d)
图2 血小板聚集和血小板呈散在分布的两帧显微血液涂片(Wright-Giemsa染色×1000)
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