嗜酸性粒细胞计数在变应性鼻炎患儿中的临床意义

doi:10.3877/cma.j.issn.2095-5820.2021.03.003

中华临床实验室管理电子杂志 ›› 2021, Vol. 09 ›› Issue (03) : 138 -142. doi: 10.3877/cma.j.issn.2095-5820.2021.03.003

实验研究

嗜酸性粒细胞计数在变应性鼻炎患儿中的临床意义

曾心睿¹, 梁嘉敏², 王怡洁¹, 陈韵³, 罗嘉莹⁴, 王峰⁴, 孙宝清⁴^,^†(

)

^1. 510182　广东广州，广州医科大学金域检验学院
^2. 510182　广东广州，广州医科大学公共卫生学院
^3. 510182　广东广州，广州市越秀区妇幼保健院检验科
^4. 510182　广东广州，广州医科大学附属第一医院　广州呼吸健康研究院　呼吸疾病国家临床医学研究中心　呼吸疾病国家重点实验室

收稿日期:2020-08-12 出版日期:2021-08-26
通信作者: 孙宝清
基金资助:
国家自然科学基金面上项目(81871376); 广州市高校创新创业教育项目(平台建设)(2020PT102)

The clinical significance of eosinophil count in patients with allergic rhinitis

Xinrui Zeng¹, Jiamin Liang², Yijie Wang¹, Yun Chen³, Jiaying Luo⁴, Feng Wang⁴, Baoqing Sun⁴^,^†()

^1. KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou Guangdong 510182, China
^2. School of Public Health, Guangzhou Medical University, Guangzhou Guangdong 510182, China
^3. Department of Clinical Laboratory, Yuexiu District Maternal and Child Health Care Hospital, Guangzhou Guangdong 510182, China
^4. The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, Guangzhou Guangdong 510182, China

Received:2020-08-12 Published:2021-08-26
Corresponding author: Baoqing Sun

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引用本文：

曾心睿, 梁嘉敏, 王怡洁, 陈韵, 罗嘉莹, 王峰, 孙宝清. 嗜酸性粒细胞计数在变应性鼻炎患儿中的临床意义[J/OL]. 中华临床实验室管理电子杂志, 2021, 09(03): 138-142.

Xinrui Zeng, Jiamin Liang, Yijie Wang, Yun Chen, Jiaying Luo, Feng Wang, Baoqing Sun. The clinical significance of eosinophil count in patients with allergic rhinitis[J/OL]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2021, 09(03): 138-142.

目的

本文旨在探讨外周血嗜酸性粒细胞计数在变应性鼻炎患儿中的临床辅助诊断价值。

方法

通过回顾性分析方法，收集在广州医科大学附属第一医院确诊的117例变应性鼻炎患儿及118例在广州市越秀区妇幼保健院体检的健康儿童检查结果，并结合变应性鼻炎严重程度，视觉模拟量表结果进行相关性分析。

结果

变应性鼻炎患儿外周血嗜酸性粒细胞较正常儿童高，嗜酸性粒细胞数与tIgE、打喷嚏、眼痒的症状相关，且不同严重程度变应性鼻炎中嗜酸性粒细胞数与症状相关性存在差异。

结论

外周血嗜酸性粒细胞计数可以辅助诊断变应性鼻炎，结合tIgE可以反映变应性鼻炎的严重程度。

关键词: 变应性鼻炎, 嗜酸粒细胞增多, 儿童, 视觉模拟量表

Objective

To investigate the clinical value of peripheral blood eosinophil count in the auxiliary diagnosis of children with allergic rhinitis.

Methods

117 children with allergic rhinitis diagnosed in the First Affiliated Hospital of Guangzhou Medical University and 118 healthy children from the physical examination of the Maternal and Children Health Care Hospital in Yuexiu District in Guangzhou were collected through retrospective analysis, and the correlation analysis was conducted based on the resultes ofthe severity of allergic rhinitis and Visual Analog Scale.

Results

Compared with healthy children, peripheral blood eosinophil count were higher in children with allergic rhinitis. The number of eosinophil in patients with allergic rhinitis was correlated with tIgE、eye itching and sneezing. There was a statistically difference in the correlation between eosinophil count and symptom in different degrees of allergic rhinitis.

Conclusions

Peripheral blood eosinophil count can assist in the diagnosis of allergic rhinitis, and combined with tIgE can reflect the severity of allergic rhinitis.

Key words: Allergic rhinitis, Eosinophilia, Children, Visual Analog Scale

表1 AR组和对照组血常规结果

指标	AR组	对照组
淋巴细胞( $109$ /L)	3.07(2.60，3.99)	3.38(2.89，4.20)
EOS( $109$ /L)	0.35(0.18，0.57)^a	0.24(0.15，0.49)
嗜碱性粒细胞( $109$ /L)	0.03(0.02，0.05)	0.03(0.02，0.04)
中性粒细胞( $109$ /L)	2.99(2.51，4.08)	2.98(2.58，3.94)
ELR	0.11(0.05，0.18)^a	0.07(0.05，0.15)
BLR	0.01(0.01，0.01)	0.01(0.01，0.01)
NLR	0.95(0.72，1.24)	0.88(0.68，1.21)

表1 AR组和对照组血常规结果

指标	AR组	对照组
淋巴细胞( $109$ /L)	3.07(2.60，3.99)	3.38(2.89，4.20)
EOS( $109$ /L)	0.35(0.18，0.57)^a	0.24(0.15，0.49)
嗜碱性粒细胞( $109$ /L)	0.03(0.02，0.05)	0.03(0.02，0.04)
中性粒细胞( $109$ /L)	2.99(2.51，4.08)	2.98(2.58，3.94)
ELR	0.11(0.05，0.18)^a	0.07(0.05，0.15)
BLR	0.01(0.01，0.01)	0.01(0.01，0.01)
NLR	0.95(0.72，1.24)	0.88(0.68，1.21)

表2 AR组症状VAS评分结果

症状指标	评分(分)
打喷嚏	3.00(2.00，4.50)
流鼻涕	3.00(2.00，5.00)
鼻塞	4.00(1.00，6.00)
鼻痒	4.00(2.00，5.00)
眼痒	2.00(0.00，4.00)
结膜充血	0.00(0.00，2.00)
流泪	1.00(0.00，1.00)
嗅觉失调	0.00(0.00，1.00)
眼脸水肿	0.00(0.00，1.00)
对睡眠的影响	2.00(1.00，5.00)
对工作或学习的影响	2.00(1.00，4.50)
对社会活动的影响	2.00(0.00，3.00)
对体力活动的影响	2.00(0.00，3.00)
对生活影响总分	8.00(4.00，14.00)
症状总分	20.97±12.10

表2 AR组症状VAS评分结果

症状指标	评分(分)
打喷嚏	3.00(2.00，4.50)
流鼻涕	3.00(2.00，5.00)
鼻塞	4.00(1.00，6.00)
鼻痒	4.00(2.00，5.00)
眼痒	2.00(0.00，4.00)
结膜充血	0.00(0.00，2.00)
流泪	1.00(0.00，1.00)
嗅觉失调	0.00(0.00，1.00)
眼脸水肿	0.00(0.00，1.00)
对睡眠的影响	2.00(1.00，5.00)
对工作或学习的影响	2.00(1.00，4.50)
对社会活动的影响	2.00(0.00，3.00)
对体力活动的影响	2.00(0.00，3.00)
对生活影响总分	8.00(4.00，14.00)
症状总分	20.97±12.10

图1 AR组各指标和AR症状的相关性分析

图2 AR组EOS和tIgE、打喷嚏、眼痒的相关性分析

图3 不同严重程度AR血常规指标和症状相关性分析

图4 中重度AR的EOS和tIgE对比分析

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