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中华临床实验室管理电子杂志 ›› 2023, Vol. 11 ›› Issue (02) : 114 -117,123. doi: 10.3877/cma.j.issn.2095-5820.2023.02.010

病例报告

一例产后获得性血友病A报告及总结分析
罗纯苑, 刘杭鑫, 李玥, 麦艳梅, 石凌波()   
  1. 511495 广东广州,广东祈福医院检验科
  • 收稿日期:2022-11-02 出版日期:2023-05-28
  • 通信作者: 石凌波

Postpartum acquired hemophilia A: a case report and review of the literature

Chunyuan Luo, Hangxin Liu, Yue Li, Yanmei Mai, Lingbo Shi()   

  1. Guangdong Clifford Hospital, Guangzhou Guangdong 511496, China
  • Received:2022-11-02 Published:2023-05-28
  • Corresponding author: Lingbo Shi
引用本文:

罗纯苑, 刘杭鑫, 李玥, 麦艳梅, 石凌波. 一例产后获得性血友病A报告及总结分析[J]. 中华临床实验室管理电子杂志, 2023, 11(02): 114-117,123.

Chunyuan Luo, Hangxin Liu, Yue Li, Yanmei Mai, Lingbo Shi. Postpartum acquired hemophilia A: a case report and review of the literature[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2023, 11(02): 114-117,123.

目的

通过分享1例产后获得性血友病A(AHA)病例并复习相关文献,提高该病的实验室诊断水平。

方法

结合1例常规凝血PT/TT结果正常而活化部分凝血活酶时间(APTT)延长的产后出血病例的实验室筛查诊断过程及相关文献报道,对该病的实验室筛查方案进行讨论。

结果

通过APTT纠正试验和血浆Ⅷ因子活性及抑制物的检测,能够快速诊断AHA。

结论

APTT纠正试验在出血性疾病方面具有重要的筛查作用。

Objective

To improve the laboratory diagnostic level of postpartum acquired hemophilia A (AHA) through sharing a case and reviewing relevant literatures.

Methods

Combined with the laboratory screening diagnosis process of a postpartum hemorrhagic case with normal PT/TT and prolonged APTT in routine coagulation detection and related literatures, the laboratory screening programme of this disease was discussed.

Results

AHA could be quickly diagnosed by APTT correction test and plasma coagulation factor Ⅷ activity and inhibitor titer assay.

Conclusions

The role of APTT correction test is crutial to screen hemorrhagic disease.

表1 凝血四项及APTT纠正试验结果
表2 检测凝血因子活性及相关凝血因子抑制物浓度
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