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中华临床实验室管理电子杂志 ›› 2023, Vol. 11 ›› Issue (04) : 241 -244. doi: 10.3877/cma.j.issn.2095-5820.2023.04.008

综述

肠道菌群促进诺如病毒感染的机制
杜青瑶, 曹颖雯, 林健雄, 郝润, 王静敏, 徐锐权, 寇晓霞()   
  1. 510182 广东广州,广州医科大学金域检验学院
  • 收稿日期:2023-05-12 出版日期:2023-11-28
  • 通信作者: 寇晓霞
  • 基金资助:
    广东省自然科学基金面上项目(2021A1515011057); 广州医科大学2023年科研能力提升计划(广医发[2023]16号)

Mechanism of gut flora promoting Norovirus infection

Qingyao Du, Yingwen Cao, Jianxiong Lin, Run Hao, Jingmin Wang, Ruiquan Xu, Xiaoxia Kou()   

  1. KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou Guangdong 510182, China
  • Received:2023-05-12 Published:2023-11-28
  • Corresponding author: Xiaoxia Kou
引用本文:

杜青瑶, 曹颖雯, 林健雄, 郝润, 王静敏, 徐锐权, 寇晓霞. 肠道菌群促进诺如病毒感染的机制[J/OL]. 中华临床实验室管理电子杂志, 2023, 11(04): 241-244.

Qingyao Du, Yingwen Cao, Jianxiong Lin, Run Hao, Jingmin Wang, Ruiquan Xu, Xiaoxia Kou. Mechanism of gut flora promoting Norovirus infection[J/OL]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2023, 11(04): 241-244.

诺如病毒(NoV)主要引起成人和儿童的流行性、自限性急性胃肠炎,是导致病毒性腹泻最主要的病原体之一。由于该病毒仍不能体外培养,目前主要利用鼠诺如病毒(MNV)感染的小鼠和组织培养模型来探究其感染机制和发病机理。国内外基于对MNV的研究提出NoV、宿主和肠道菌群之间的相互作用会影响病毒的感染性,包括促进或抑制NoV感染。本文对肠道菌群促进NoV感染的机制以及宿主肠道在NoV感染后通过肠道菌群引发的免疫反应进行综述和分析,为更进一步研究NoV的感染机制提供新视角和思路。

Norovirus (NoV) is a major cause of epidemic and self-limiting acute gastroenteritis in adults and children, and is one of the main pathogens causing viral diarrhea. Since the virus is still unable to be cultured in vitro, murine Norovirus (MNV) infected mice and tissue culture models are mainly used to explore the infection mechanism and pathogenesis of MNV. Based on the research of MNV both domestically and internationally, it has been proposed that the interaction between NoV, host, and gut microbiota can affect the infectivity of the virus, including promoting or inhibiting infection of NoV. This article reviews and analyzes the mechanism of gut flora promoting norovirus infection and the immune response induced by gut flora in the intestine after norovirus infection, providing new perspectives and ideas for further research on the infection mechanism of norovirus.

1
王建,陈秋霞,王海燕,等. 广州市市售牡蛎诺如病毒污染情况分析[J]. 华南预防医学, 2022, 48(8): 981-984.
2
易中恒, 杨俊杰, 李薇. 诺如病毒感染的疾病负担及防治[J]. 微生物学免疫学进展, 2022, 50(3): 98-103.
3
刘小平, 宋永胜, 乌云桑. 一起诺如病毒引起的学校感染性腹泻暴发调查[J]. 中国卫生检验杂志, 2022, 32(5): 625-627, 631.
4
梁耀民, 陆胤波, 曹颖雯, 等. 诺如病毒和肠道菌群的互作关系及机制研究进展[J]. 病毒学报, 2021, 37(5): 1215-1220.
5
廖颖茵, 薛亮, 高珺珊, 等. 诺如病毒分子结构特征及其衣壳蛋白功能研究进展[J]. 病毒学报, 2021, 37(2): 459-464.
6
张静, 常昭瑞, 孙军玲, 等. 我国诺如病毒感染性腹泻流行现状及防制措施建议[J]. 疾病监测, 2014, 29(7): 516-521.
7
ROBINSON C M, JESUDHASAN P R, PFEIFFER J K. Bacterial lipopolysaccharide binding enhances virion stability and promotes environmental fitness of an enteric virus[J]. Cell host and microbe, 2014, 15(1): 36-46.
8
PEñA-GIL N, SANTISO-BELLóN C, GOZALBO-ROVIRA R, et al. The role of host glycobiology and gut microbiota in Rotavirus and Norovirus infection, an update[J]. Nternational journal of molecular sciences, 2021, 22(24): 13473.
9
MURAKAMI K, TENGE V R, KARANDIKAR U C, et al. Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids[J]. Proceedings of the national academy of sciences of the United States of America, 2020, 117(3): 1700-1710.
10
JONES M K, WATANABE M, ZHU S, et al. Enteric bacteria promote human and mouse norovirus infection of B cells[J]. Science, 2014, 346(6210): 755-759.
11
BALDRIDGE M T, NICE T J, MCCUNE B T, et al. Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection[J]. Science, 2015, 347(6219): 266-269.
12
RUBIO-DEL-CAMPO A, COLL-MARQUéS J M, YEBRA M J, et al. Noroviral p-particles as an in vitro model to assess the interactions of noroviruses with probiotics[J]. PloS one, 2014, 9(2): e89586.
13
LEI S, RAMESH A, TWITCHELL E, et al. High protective efficacy of probiotics and rice bran against human Norovirus infection and diarrhea in gnotobiotic pigs[J]. Frontiers in microbiology, 2016, 7: 1699.
14
LI Y, GAO J, XUE L, et al. Determination of antiviral mechanism of centenarian gut-derived limosilactobacillus fermentum against Norovirus[J]. Frontiers in nutrition, 2022, 9: 812623.
15
ATKINSON M A, BOWMAN M A, CAMPBELL L, et al. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes[J]. The journal of clinical investigation, 1994, 94(5): 2125-2129.
16
ZARGARI SAMANI O, MAHMOODNIA L, IZAD M, et al. Alteration in CD8+ T cell subsets in enterovirus-infected patients: An alarming factor for type 1 diabetes mellitus[J]. The Kaohsiung journal of medical sciences, 2018, 34(5): 274-280.
17
PATIN N V, PEñA-GONZALEZ A, HATT J K, et al. The role of the gut microbiome in resisting Norovirus infection as revealed by a human challenge study[J]. MBio, 2020, 11(6): e02634-20.
18
文海聆, 姚业科, 唐志林. 双歧杆菌乳杆菌三联活菌片辅助治疗诺如病毒性肠炎的临床效果分析[J]. 数理医药学杂志, 2020, 33(8): 1167-1169.
19
CANNON J L, SEABOLT M H, XU R, et al. Gut microbiome changes occurring with Norovirus infection and recovery in infants enrolled in a longitudinal birth cohort in Leon, Nicaragua[J]. Viruses, 2022, 14(7): 1395.
20
程如越, 李鸣, 黄承钰, 等. 双歧杆菌防治儿童过敏性疾病的研究进展[C]//中国营养学会,中国疾病预防控制中心营养与健康所, 农业部食品与营养发展研究所,中科院上海生科院营养科学研究所.中国营养学会第十三届全国营养科学大会暨全球华人营养科学家大会论文集, 2017: 74.
21
TARRIS G, DE ROUGEMONT A, CHARKAOUI M, et al. Enteric viruses and inflammatory bowel disease[J]. Viruses, 2021, 13(1): 104.
22
李涵博, 丛鑫, 段招军. GII.26型诺如病毒的组织血型抗原结合特征[J]. 病毒学报, 2021, 37(6): 1310-1316.
23
ALMAND E A, MOORE M D, OUTLAW J, et al. Human norovirus binding to select bacteria representative of the human gut microbiota [J]. PloS one, 2017, 12(3): e0173124.
24
CONG X, LI H B, SUN X M, et al. Functional and structural characterization of Norovirus GII.6 in recognizing histo-blood group antigens[J]. Virologica sinica, 2023, 38(1): 56-65.
25
KARST S M. Identification of a novel cellular target and a co-factor for norovirus infection-B cells & commensal bacteria[J]. Gut microbes, 2015, 6(4): 266-271.
26
OKA T, STOLTZFUS G T, ZHU C, et al. Attempts to grow human noroviruses, a sapovirus, and a bovine norovirus in vitro[J]. PloS one, 2018, 13(2): e0178157.
27
丛鑫. 诺如病毒与寡糖结合机制的研究[D]. 北京:中国疾病预防控制中心, 2019.
28
GRAU K R, ZHU S, PETERSON S T, et al. The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type Ⅲ interferon[J]. Nature microbiology, 2020, 5(1): 84-92.
29
LUCERO Y, MATSON D O, ASHKENAZI S, et al. Norovirus: Facts and reflections from past, present, and future[J]. Viruses, 2021, 13(12): 2399.
30
GRAZIANO V R, WEI J, WILEN C B. Norovirus attachment and entry[J]. Viruses, 2019, 11(6): 495.
31
INAGAKI T, MOSCHETTA A, LEE Y K, et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor[J]. Proceedings of the national academy of sciences of the United States of America, 2006, 103(10): 3920-3925.
32
ZHANG Y, KAST-WOELBERN H R, EDWARDS P A. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation[J]. The journal of biological chemistry, 2003, 278(1): 104-110.
33
NICE T J, BALDRIDGE M T, MCCUNE B T, et al. Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity[J]. Science, 2015, 347(6219): 269-273.
34
HASSAN E, BALDRIDGE M T. Norovirus encounters in the gut: Multifaceted interactions and disease outcomes[J]. Mucosal immunology, 2019, 12(6): 1259-1267.
35
ABT M C, OSBORNE L C, MONTICELLI L A, et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity[J]. Immunity, 2012, 37(1): 158-170.
36
WALKER F C, BALDRIDGE M T. Interactions between noroviruses, the host, and the microbiota [J]. Current opinion in virology, 2019, 37: 1-9.
37
MORI K, KONISHI N, SUZUKI Y, et al. Comparison between patients with norovirus-related gastroenteritis and asymptomatic carriers with respect to distribution of antibody-complexed viral particles and intestinal flora[J]. Journal of medical virology, 2018, 90(12): 1882-1887.
38
STEYER A, MIČETIĆ-TURK D, FIJAN S. The efficacy of probiotics as antiviral agents for the treatment of rotavirus gastrointestinal infections in children: An updated overview of literature[J]. Microorganisms, 2022, 10(12): 2392.
39
LI D, BREIMAN A, LE PENDU J, et al. Anti-viral effect of Bifidobacterium adolescentis against Noroviruses[J]. Frontiers in microbiology, 2016, 7: 864.
40
ABOUBAKR H A, EL-BANNA A A, YOUSSEF M M, et al. Antiviral effects of lactococcus lactis on feline Calicivirus, a human Norovirus surrogate[J]. Food and environmental virology, 2014, 6(4): 282-289.
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