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中华临床实验室管理电子杂志 ›› 2023, Vol. 11 ›› Issue (04) : 241 -244,255. doi: 10.3877/cma.j.issn.2095-5820.2023.04.008

综述

肠道菌群促进诺如病毒感染的机制
杜青瑶, 曹颖雯, 林健雄, 郝润, 王静敏, 徐锐权, 寇晓霞()   
  1. 510182 广东广州,广州医科大学金域检验学院
  • 收稿日期:2023-05-12 出版日期:2023-11-28
  • 通信作者: 寇晓霞
  • 基金资助:
    广东省自然科学基金面上项目(2021A1515011057); 广州医科大学2023年科研能力提升计划(广医发[2023]16号)

Mechanism of gut flora promoting Norovirus infection

Qingyao Du, Yingwen Cao, Jianxiong Lin, Run Hao, Jingmin Wang, Ruiquan Xu, Xiaoxia Kou()   

  1. KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou Guangdong 510182, China
  • Received:2023-05-12 Published:2023-11-28
  • Corresponding author: Xiaoxia Kou
引用本文:

杜青瑶, 曹颖雯, 林健雄, 郝润, 王静敏, 徐锐权, 寇晓霞. 肠道菌群促进诺如病毒感染的机制[J]. 中华临床实验室管理电子杂志, 2023, 11(04): 241-244,255.

Qingyao Du, Yingwen Cao, Jianxiong Lin, Run Hao, Jingmin Wang, Ruiquan Xu, Xiaoxia Kou. Mechanism of gut flora promoting Norovirus infection[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2023, 11(04): 241-244,255.

诺如病毒(NoV)主要引起成人和儿童的流行性、自限性急性胃肠炎,是导致病毒性腹泻最主要的病原体之一。由于该病毒仍不能体外培养,目前主要利用鼠诺如病毒(MNV)感染的小鼠和组织培养模型来探究其感染机制和发病机理。国内外基于对MNV的研究提出NoV、宿主和肠道菌群之间的相互作用会影响病毒的感染性,包括促进或抑制NoV感染。本文对肠道菌群促进NoV感染的机制以及宿主肠道在NoV感染后通过肠道菌群引发的免疫反应进行综述和分析,为更进一步研究NoV的感染机制提供新视角和思路。

Norovirus (NoV) is a major cause of epidemic and self-limiting acute gastroenteritis in adults and children, and is one of the main pathogens causing viral diarrhea. Since the virus is still unable to be cultured in vitro, murine Norovirus (MNV) infected mice and tissue culture models are mainly used to explore the infection mechanism and pathogenesis of MNV. Based on the research of MNV both domestically and internationally, it has been proposed that the interaction between NoV, host, and gut microbiota can affect the infectivity of the virus, including promoting or inhibiting infection of NoV. This article reviews and analyzes the mechanism of gut flora promoting norovirus infection and the immune response induced by gut flora in the intestine after norovirus infection, providing new perspectives and ideas for further research on the infection mechanism of norovirus.

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