目的

调查广州地区女性不孕症患者生殖道解脲脲原体（UU）、人型支原体（MH）和沙眼衣原体（CT）的临床感染情况。

方法

选择广东省妇幼保健院门诊505例女性不孕症患者设为不孕症组，其中原发性不孕症患者215例（原发不孕组），继发性不孕症患者290例（继发不孕组），另取同时期60例在广东省妇幼保健院正常妊娠并进行产检的女性作为对照组，所有患者均行CT抗原检测及UU、MH的培养和药敏试验。

结果

不孕症组患者UU、MH和CT的单项感染阳性率分别为46.1%、8.5%和6.5%，明显高于对照组（P＜0.05）；不孕症组患者单项感染的阳性率为61.2%（309/505），混合感染的阳性率为11.9%（60/505），与对照组比较，混合感染阳性率差异无统计学意义（P＞0.05）。原发和继发不孕组患者的UU、MH和CT单项感染阳性率和混合感染阳性率相近，两组患者单项感染和混合感染阳性率差异均无统计学意义（P＞0.05）；UU和UU+MH混合感染均对强力霉素和交沙霉素敏感性较强；对于不同年龄段的患者，其UU的阳性率差异有统计学意义（P＜0.05），其中以≥41岁组女性UU阳性率最高，MH和CT阳性率在各年龄组差异均无统计学意义（P＞0.05）。

结论

女性UU、MH、CT感染的阳性率与不孕症的发生有关联，对于各类不孕症的女性患者应该加强上述病原体的筛查。

Objective

To investigate the clinical infection status of ureaplasma urealyticum (UU),mycoplasma hominis (MH) and chlamydia trachomatis (CT) in the genital tract of female infertility patients in Guangzhou area.

Methods

505 cases of female infertility patients in outpatient clinics of Guangdong Women and Children Hospital were selected, including 215 cases of primary infertility patients (primary infertility group) and 290 cases of secondary infertility patients (secondary infertility group), and 60 cases of normal pregnancy and obstetrics examination in Guangdong Women and Children Hospital in the same period of time were taken as the control group, and all of the patients were tested for CT antigen and the cultivation of UU and MH, as well as drug sensitivity test.

Results

The positive rates of single infections of UU, MH and CT in patients in the infertility group were 46.1%, 8.5% and 6.5%, respectively, which were significantly higher than those in the control group (P＜0.05); the positive rate of single infections in patients in the infertility group was 61.2% (309/505), and that of mixed infections was 11.9% (60/505), and there was no statistical significance in the difference of positive rates of mixed infections when compared with those in the control group (P＞0.05). The positive rates of UU, MH and CT single infections and mixed infections were similar in the primary and secondary infertility groups, and there was no statistically significant difference in the positive rates of single infections and mixed infections between the two groups (P＞0.05); UU and UU+MH mixed infections were both more sensitive to doxycycline and cosyntropin; the difference in the positive rate of UU was statistically significant in patients of different ages (P＜0.05), with the highest UU positivity rate in women in the ≥41-year-old group, and the differences in MH and CT positivity rates were not statistically significant in all age groups (P＞0.05)

Conclusion

Positive rates of female genital tract UU, MH, and CT infections are positively correlated with the occurrence of infertility, and female patients with all types of infertility should be intensely screened for these pathogens.