糖化血红蛋白（HbA_1c）作为糖尿病筛查与诊断的核心指标，其检测的准确性与标准化对临床诊疗至关重要。2024年国家卫生健康委员会发布了WS/T 461-2024《糖化血红蛋白检测指南》。作为2015版标准的修订版，该标准紧密衔接国际前沿并结合我国临床实践，进一步细化了HbA_1c检测全流程质量控制要求。本文从标准修订背景、过程及基本情况入手，重点解读了术语定义、生物学特性与临床意义、检验全流程技术要求、质量控制与保证等核心修订要点。该标准的修订与实施，标志着我国HbA_1c检测质量控制要求的深化，将推动我国HbA_1c检测质量与标准化水平提升，为糖尿病精准防治提供坚实技术保障。

With the significant increase in the prevalence of diabetes in China, glycated hemoglobin (HbA_1c), as a core indicator for the screening and diagnosis of diabetes, its detection accuracy and standardization are crucial for clinical diagnosis and treatment. In 2024, the National Health Commission issued WS/T 461-2024 "Guidelines for Glycated Hemoglobin Detection". As a revised version of the 2015 standard, this updated standard closely aligns with international advances and combines with China's clinical practice, further refining the quality control requirements throughout the entire process of HbA_1c detection. Starting from the background, process and basic situation of the standard revision, this paper focuses on interpreting the core revised key points such as terminology and definitions, biological characteristics and clinical significance, technical requirements for the entire inspection process (pre-inspection, in-inspection, post-inspection), and quality control and assurance. The revision and implementation of this standard mark the deepening of the quality control requirements for HbA1c detection in China, which will promote the improvement of the quality and standardization level of HbA_1c detection in China and provide a solid technical guarantee for the precise prevention and treatment of diabetes.