切换至 "中华医学电子期刊资源库"
高级检索
中华临床实验室管理电子杂志

中华临床实验室管理电子杂志 ›› 2021, Vol. 09 ›› Issue (01) : 1 -5. doi: 10.3877/cma.j.issn.2095-5820.2021.01.001

所属专题： 文献；

综述

过敏原组分诊断在食物过敏中的研究进展
王美仪1, 孙宝清2, 黄惠敏2,†()   
  1. 1. 510120　广东广州，广州医科大学金域检验学院
    2. 510120　广东广州，呼吸疾病国家重点实验室，呼吸疾病国家临床研究中心，广州呼吸健康研究院，广州医科大学附属第一医院，变态反应科
  • 收稿日期:2020-10-13 出版日期:2021-02-28
  • 通信作者: 黄惠敏
  • 基金资助:
    广州市中医药和中西医结合科技项目(20202A011017); 广州医科大学附属第一医院培育项目(ZH201818); 广东省医学科研基金项目(A2019224)

Research progress on the component-resolved diagnosis in food allergy

Meiyi Wang1, Baoqing Sun2, Huimin Huang2,†()   

  1. 1. KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 510006, China
    2. State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
  • Received:2020-10-13 Published:2021-02-28
  • Corresponding author: Huimin Huang
全文 ( ) 下载PDF ( ) 导出引用
引用本文：

王美仪, 孙宝清, 黄惠敏. 过敏原组分诊断在食物过敏中的研究进展[J]. 中华临床实验室管理电子杂志, 2021, 09(01): 1-5.

Meiyi Wang, Baoqing Sun, Huimin Huang. Research progress on the component-resolved diagnosis in food allergy[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2021, 09(01): 1-5.

食物过敏(FA)诱发的过敏症状复杂多样，不仅影响着患者的生活质量，严重的还会威胁到患者生命。近年来，过敏原组分诊断(CRD)受到了广泛的关注，在诊断食物过敏方面有一定的临床价值。本文就食物CRD在国内外的研究现状、常见致敏食物组分的特点、CRD在食物过敏中的应用价值、食物组分的检测技术等方面进行阐述，为CRD在食物过敏中的研究方向提供新的思路，对食物过敏的预防和临床诊治提供参考依据。

关键词: 食物过敏, 过敏原组分诊断, 食物组分

The allergic symptoms induced by food allergy (FA) are complex and varied, which not only impact negatively on quality of life, but also threatens the lives in severe cases. In recent years, component-resolved diagnostics (CRD) has aroused extensive attention and has certain clinical value in the diagnosis of food allergies. In this review, the research status of food CRD at home and abroad, the characteristics of common allergenic food components, the application value of CRD in food allergy, and the detection technology of food components were summarized, so as to provide new ideas for the research direction of CRD in food allergy and reference for the prevention, clinical diagnosis and treatment of food allergy.

Key words: Food allergy, Component-resolved diagnostics, Food component
1
Canonica GW, Ansotegui IJ, Pawankar R, et al. A WAO-ARIA-GALEN consensus document on molecular-based allergy diagnostics[J]. World Allergy Organ J, 2013, 6(1):83-99.
2
Vazquez-Ortiz M, Pascal M, Jimenez-Feijoo R, et al. Ovalbumin-specific IgE/IgG4 ratio might improve the prediction of cooked and uncooked egg tolerance development in egg-allergic children[J]. Clin Exp Allergy, 2014, 44(4):579-588.
3
Chiang WC, Pons L, Kidon MI, et al. Serological and clinical characteristics of children with peanut sensitization in an Asian community[J]. Pediatr Allergy Immunol, 2010, 21(2):429-438.
4
Samady W, Warren C, Kohli S, et al. The prevalence of atopic dermatitis in children with food allergy[J]. Ann Allergy Asthma Immunol, 2019, 122(6):656-657.
5
Venkataraman D, Erlewyn-Lajeunesse M, Kurukulaaratchy RJ, et al. Prevalence and longitudinal trends of food allergy during childhood and adolescence: Results of the isle of wight birth cohort study[J]. Clin Exp Allergy, 2018, 48(4):394-402.
6
Jiang N, Yin J, Wen L, et al. Characteristics of anaphylaxis in 907 chinese patients referred to a tertiary allergy center: A retrospective study of 1,952 episodes[J]. Allergy Asthma Immunol Res, 2016, 8(4):353-361.
7
Fiocchi A, Dahdah L, Albarini M, et al. Cow's milk allergy in children and adults[J]. Chem Immunol Allergy, 2015, 101:114-123.
8
Jessadapakorn W, Sangsupawanich P, Wootipoom N, et al. Component-resolved diagnostics in Thai children with cow's milk and egg allergy[J]. Asian Pac J Allergy Immunol, 2017, 35(4):179-185.
9
Li J, Zhang J, Qiong C, et al. Component resolved diagnostic study of cow's milk allergy in infants and young children in northern China[J]. Int Immunopharmacol, 2018, 61:126-131.
10
Tuano KS, Davis CM. Utility of component-resolved diagnostics in food allergy[J]. Curr Allergy Asthma Rep, 2015, 15(6):32.
11
D'Auria E, Salvatore S, Pozzi E, et al. Cow's milk allergy: immunomodulation by dietary intervention[J]. Nutrients, 2019, 11(6):1399.
12
Min TK, Jeon YH, Yang HJ, et al. The Clinical usefulness of IgE antibodies against egg white and its components in korean children[J]. Allergy Asthma Immunol Res, 2013, 5(3):138-142.
13
De Silva C, Dhanapala P, King S, et al. Immunological comparison of native and recombinant hen's egg yolk allergen, chicken serum albumin (Gal d 5), produced in kluveromyces lactis[J]. Nutrients, 2018, 10(6):757.
14
Palosuo K, Kukkonen AK, Pelkonen AS, et al. Gal d 1-specific IgE predicts allergy to heated egg in Finnish children[J]. Pediatric Allergy and Immunology, 2018, 29(6):637-643.
15
Urisu A, Kondo Y, Tsuge I. Hen's egg allergy[J]. Chem Immunol Allergy, 2015, 101:124-130.
16
Metcalfe JR, Vaz ND, Makrides M, et al. Elevated IL-5 and IL-13 responses to egg proteins predate the introduction of egg in solid foods in infants with eczema[J]. Clin Exp Allergy, 2016, 46(2):308-316.
17
Raulf M. Allergen component analysis as a tool in the diagnosis and management of occupational allergy[J]. Mol Immunol, 2018, 100:21-27.
18
Gomez Casado C, Garrido Arandia M, Pereira C, et al. Component-resolved diagnosis of wheat flour allergy in baker's asthma[J]. J Allergy Clin Immunol, 2014, 134(2):480-483.
19
Matricardi PM, Kleine Tebbe J, Hoffmann HJ, et al. EAACI molecular allergology user's guide[J]. Pediatr Allergy Immunol, 2016, 27(23):1-250.
20
Kattan JD, Sampson HA. Clinical reactivity to soy is best identified by component testing to Gly m 8[J]. J Allergy Clin Immunol Pract, 2015, 3(6):970.
21
Klemans RJB, Knol EF, Michelsen Huisman A, et al. Components in soy allergy diagnostics: Gly m 2S albumin has the best diagnostic value in adults[J]. Allergy, 2013, 68(11):1396-1402.
22
张雅君, 张浩, 杨选, 等. 花生主要致敏物质及其脱敏方法研究进展[J]. 食品科学, 2014, (17):312-318.
23
Nilsson C, Berthold M, Mascialino B, et al. Accuracy of component-resolved diagnostics in peanut allergy: Systematic literature review and meta-analysis[J]. Pediatr Allergy Immunol, 2020, 31(3):303-314.
24
Teppo H, Revonta M, Haahtela T. Allergic rhinitis and asthma have generally good outcome and little effect on quality of life a 20-year follow-up[J]. Allergy, 2011, 66(8):1123-1125.
25
Suratannon N, Ngamphaiboon J, Wongpiyabovorn J, et al. Component-resolved diagnostics for the evaluation of peanut allergy in a low-prevalence area[J]. Pediatr Allergy Immunol, 2013, 24(7):665-670.
26
Uotila R, Rontynen P, Pelkonen AS, et al. For hazelnut allergy, component testing of Cor a 9 and Cor a 14 is relevant also in birch-endemic areas[J]. Allergy, 2020, 75(11):2977-2980.
27
Masthoff LJ, Mattsson L, Zuidmeer Jongejan L, et al. Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults[J]. J Allergy Clin Immunol, 2013, 132(2):393-399.
28
Calamelli E, Liotti L, Beghetti I, et al. Component-resolved diagnosis in food allergies[J]. Medicina (Kaunas). 2019, 55(8):498.
29
Johnston EB, Kamath SD, Iyer SP, et al. Defining specific allergens for improved component-resolved diagnosis of shrimp allergy in adults[J]. Mol Immunol, 2019, 112:330-337.
30
Carnés J, López Matas MA, Moya R, et al. In vivo diagnosis with purified tropomyosin comparison of tropomyosin sensitization in shellfish and mite allergic patients[J]. J Allergy Clin Immunol, 2016, 137(2): AB140.
31
Tobajas AP, Agullo Garcia A, Cubero JL, et al. Effect of high pressure and pulsed electric field on denaturation and allergenicity of Pru p 3 protein from peach[J]. Food Chem, 2020, 321:126745.
32
Takaiwa F, Ogo Y and Wakasa Y. Specific region affects the difference in accumulation levels between apple food allergen Mal d 1 and birch pollen allergen Betv1 which are expressed in vegetative tissues of transgenic rice[J]. Plant Mol Biol, 2018, 98(4-5):439-454.
33
Asaumi T, Yanagida N, Sato S, et al. Negative act d 8 indicates systemic kiwifruit allergy among kiwifruit-sensitized children[J]. Pediatr Allergy Immunol, 2017, 28(3):291-294.
34
Comberiati P, Colavita L, Minniti F, et al. Utility of specific IgE to ara h 2 in italian allergic and tolerant children sensitized to peanut[J]. Int J Mol Cell Med, 2016, 5(3):160-166.
35
Bian Y, Liu C, She T, et al. Development of a light-initiated chemiluminescent assay for the quantitation of sIgE against egg white allergens based on component-resolved diagnosis[J]. Anal Bioanal Chem, 2018, 410(5):1501-1510.
36
罗文婷, 韦妮莉, 郑佩燕, 等. 多变应原致敏呼吸道变应性疾病患者的112种变应原组分分布[J]. 中华检验医学杂志, 2015, 38(6):412-415.
37
Griffiths RLM, El Shanawany T, Jolles SRA, et al. Comparison of the performance of skin prick, immunoCAP, and ISAC tests in the diagnosis of patients with allergy[J]. Int Arch Allergy Immunol, 2017, 172(4):215-223.
38
Sievers S, Cretich M, Gagni P, et al. Performance of a polymer coated silicon microarray for simultaneous detection of food allergen-specific IgE and IgG4[J]. Clinical & Experimental Allergy, 2017, 47(8):1057-1068.
39
孙一帆, 黄建芳, 王彩霞, 等. 中国人的虾、蟹致敏过敏原组分分析[J]. 中国免疫学杂志, 2014, 30(10):1325-1329.
40
Gasilova N, Girault HH. Component-resolved diagnostic of cow's milk allergy by immunoaffinity capillary electrophoresis-matrix assisted laser desorption/ionization mass spectrometry[J]. Anal Chem, 2014, 86(13):6337-6345.
No related articles found!
阅读次数
全文


摘要

版权所有 中华医学会 中华医学电子音像出版社有限责任公司  京ICP备14006079号-1  网络出版服务许可证：(署)网出证(京)字第075号