Progress of the protein biomarkers for Alzheimer's disease

doi:10.3877/cma.j.issn.2095-5820.2014.02.007

Abstract

Abstract:

Alzheimer's disease is a kind of neuron degenerative disorders which is characterized by progressive and irreversible loss of brain neurons, cognitive disorders, memory impairment are the main clinical features. The aging of the population gives a sharp rise in the number of AD patients. Therefore, screening and finding new sensitive and specific biomarkers, especially early AD biornarkers, is very important for improving the AD patients survival rate and quality of life, it has become the key of early diagnosis and treatment of AD. In this paper,the progress of the protein biomarkers for AD is reviewed.

Key words: Alzheimer's disease, Protein biomarkers

Ping Hong, Peichang Wang. Progress of the protein biomarkers for Alzheimer's disease[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2014, 02(02): 98-100.

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References 26

1	Blennow K, de Leon MJ, Zetterberg H. Alzheimer's disease[J]. Lancet,2006,368(9533):387-403.
2	Laxton AW, Lozano AM. Deep brain stimulation for the treatment of Alzheimer disease and dementias[J]. World Neurosurg, 2013,80(3-4):S28 e1-8.
3	Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease[J].Alzheimers Dement, 2011,7(3):270-279.
4	Alzheimer's A. 2012 Alzheimer's disease facts and figures[J].Alzheimers Dement, 2012,8(2):131-168.
5	Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease:progress and problems on the road to therapeutics[J]. Science,2002,297(5580):353-356.
6	Lee VM, Goedert M, Trojanowski JQ. Neurodegenerative tauopathies[J]. Ann Rev Neurosci, 2001,24:1121-1159.
7	Wyss-Coray T. Inflammation in Alzheimer disease: driving force,bystander or beneficial response[J]? Nat Med, 2006,12(9):1005-1015.
8	Graeber MB, Streit WJ. Microglia: biology and pathology[J]. Acta Neuropathol, 2010,119(1):89-105.
9	Granic I, Dolga AM, Nijholt IM, et al. Inflammation and NFkappaB in Alzheimer's disease and diabetes[J]. J Alzheimers Dis,2009,16(4):809-821.
10	Reiman EM, McKhann GM, Albert MS, et al. Alzheimer's disease:implications of the updated diagnostic and research criteria[J]. J Clin Psychiatry, 2011,72(9):1190-1196.
11	Sperling RA, Johnson KA. Dementia: new criteria but no new treatments[J]. Lancet Neurol, 2012,11(1):4-5.
12	van Rossum IA, Vos S, Handels R, et al. Biomarkers as predictors for conversion from mild cognitive impairment to Alzheimertype dementia: implications for trial design[J]. J Alzheimers Dis,2010,20(3):881-891.
13	Lewczuk P, Kamrowski-Kruck H, Peters O, et al. Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study[J]. Mol Psychiatry, 2010,15(2):138-145.
14	Jack CR Jr, Holtzman DM. Biomarker modeling of Alzheimer's disease[J]. Neuron, 2013,80(6):1347-1358.
15	Dickerson BC, Wolk DA. Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampal volume with spinal fluid amyloid-beta and tau[J]. Front Aging Neurosci, 2013,5:55.
16	Zhang J, Zhang CH, Li RJ, et al. Accuracy of urinary AD7c-NTP for diagnosing Alzheimer's disease: A systematic review and Metaanalysis[J]. J Alzheimers Dis, 2014, 40(1): 153-159.
17	Gupta VB, Sundaram R, Martins RN. Multiplex biomarkers in blood[J]. Alzheimers Res Ther, 2013,5(3):31.
18	Snyder HM, Carrillo MC, Grodstein F, et al. Developing novel bloodbased biomarkers for Alzheimer's disease[J]. Alzheimers & Dement,2014,10(1):109-114.
19	Nagele E, Han M, Demarshall C, et al. Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera[J]. PloS One, 2011,6(8):e23112.
20	Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome[J]. Nature, 2001,409(6822):860-921.
21	MacBeath G, Schreiber SL. Printing proteins as microarrays for highthroughput function determination[J]. Science, 2000,289(5485):1760-1763.
22	Braun P, Hu Y, Shen B, et al. Proteome-scale purification of human proteins from bacteria[J]. Proc Natl Acad Sci U S A, 2002,99(5):2654-2659.
23	Ray S, Britschgi M, Herbert C, et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins[J].Nat Med, 2007,13(11):1359-1362.
24	Klose J. Protein mapping by combined isoelectric focusing and electrophoresis of mouse tissues. A novel approach to testing for induced point mutations in mammals[J]. Humangenetik,1975,26(3):231-243.
25	Roche S, Dauvilliers Y, Tiers L, et al. Autoantibody profiling on high-density protein microarrays for biomarker discovery in the cerebrospinal fluid[J]. J Immunol Methods, 2008,338(1-2):75-78.
26	Reddy MM, Wilson R, Wilson J, et al. Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening[J]. Cell, 2011,144(1):132-142.

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