Relationship between the regulation of apolipoprotein M and lipid metabolism related diseases

doi:10.3877/cma.j.jssn.2095-5820.2014.02.006

Abstract

Abstract:

Apolipoprotein M (apoM) with molecular weight of 26 000, a kind of apolipoprotein found in 1999, is a member of the superfamily of lipid protein. ApoM is mainly expressed in human liver parenchymal cells and kidney proximal renal tubular epithelial cells, which is rarely expressed in the other tissues. Up to now, the structure and localization of the apoM gene is relatively clear; however, the regulation mechanism of apoM is very complex which need to be further studied. Plasma apoM mainly exists in the high density lipoprotein (HDL) particles, and is associated with the formation of pre-β-HDL and the reverse cholesterol transport. The further study of the regulation and function of apoM will provide more new clues for the study of diseases associated with lipid metabolism, such as coronary heart disease and diabetes.

Key words: Apolipoprotein M, Lipid metabolism

Yinyin Liu, Min Hu. Relationship between the regulation of apolipoprotein M and lipid metabolism related diseases[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2014, 02(02): 93-97.

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