Lactate dehydrogenase isoenzymes and clinical significance in tumor diagnosis

doi:10.3877/cma.j.issn.2095-5820.2015.02.005

Abstract

Abstract:

From the point of metabolism, the most distinctive feature of cancer cells is that they preferentially draw energy through glycolysis, even under oxygen-sufficient conditions. Lactate dehydrogenases (LDHs) are nicotinamide adenine dinucleotide trihydrate (NAD) dependent tetrameric isoenzymes including at least six classes. LDH catalyzes the reversible conversion of pyruvate to lactate at the final step of the glycolytic pathway and plays a crucial role in tumor maintenance. In this review, we summarize the properties of LDH isoenzymes and discuss their significances in tumor diagnosis，providing promising prospect for tumor diagnosis and therapy.

Key words: Lactate dehydrogenase, Aerobic glycolysis, Tumor, Diagnosis

Qinglian Zhang, Qingyun Zhang. Lactate dehydrogenase isoenzymes and clinical significance in tumor diagnosis[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2015, 03(02): 83-87.

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