To investigate the distribution of drug-resistant bacteria in clinical samples in our hospital, and provide evidence for clinical application and management of antibiotics.

Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Acinetobacter baumannii were the top four bacteria that collected from our hospital in 2015. Drug resistance of the 1 049 Escherichia coli strains, 644 Klebsiella pneumonia strains, 402 Pseudomonas aeruginosa strains and 354 Acinetobacter baumannii strains were retrospectively analyzed by WHONET5.6.

The drug resistance rates of 1 049 E.coli strains, and 644 Klebsiella pneumonia strains to 21 antibiotics (including imipenem) ranged from 2.0% to 82.0% and 6.2% to 73.9% respectively. Bacterial drug resistance rates of 402 Pseudomonas aeruginosa strains to 12 antibiotics including imipenem ranged from 6.2% to 22.4% and the rates for 354 Acinetobacter baumannii strains to 13 antibacterial ranged from 36.4% to 70.9%. E.coli were mainly isolated from urine specimens (58.2%), followed by sputum specimens (12.8%) and blood specimens (12.5%). In contrast, 63.2% of Klebsiella pneumonia strains, 74.1% of Pseudomonas aeruginosa strains and 89.2% Acinetobacter baumannii strains were isolated from sputum. E.coli was the primary bacteria that distributed in the urological ward (22.9%) while Klebsiella pneumonia was the primary bacteria that distributed in children ward (13.8%). Pseudomonas aeruginosa mainly distributed in Intensive Care Unit (ICU) (16.4%) and Acinetobacter baumannii also mainly distributed in ICU (26.3%) and Respiratory Intensive Care Unit (19.2%).

The drug resistance rates of bacteria to antibiotics were wide-ranging in our hospital and the distribution of bacteria varied widely. Clinicians should understand the pathogenic bacteria and drug-resistant bacteria distribution in the hospital in order to promote rational medicine utilization.