Analysis of drug resistance of Klebsiella pneumonia isolated from different specimens in hospital

doi:10.3877/cma.j.issn.2095-5820.2019.01.008

Abstract

Abstract:

Objective

To monitor the antimicrobial resistance of Klebsiella pneumonia isolated from different specimens and different ward areas in the hosiptal as to provide theoretical basis for the rational use of antimicrobial agents in clinic.

Methods

The antimicrobial resistance of Klebsiella pneumonia strains isolated during January 1, 2016 and December 31 were analyzed by WHONET 5.6 software. These Klebsiella pneumonia strains were isolated from different specimens: 445 from sputum, 181 from urine and 58 from blood) and different wards (143 form Pediatric ward, 74 from ICU ward and 71 from Neurosurgery ward).

Results

The resistant rates of Klebsiella pneumoniae isolated from blood, sputum and urine samples to imipenem were 5.17%, 6.07% and 7.63% respectively. The resistant rates of Klebsiella pneumoniae isolated from ICU ward, Neurosurgery ward and Pediatric ward to imipenem were 14.86%, 8.48% and 8.39% respectively.

Conclusion

The resistant rates of Klebsiella pneumoniae isolated from different specimens and different ward areas were quite different. Clinicians should understand the drug resistance of Klebsiella pneumonia isolated from different sources in time as to improve the accuracy of clinician experience medication.

Key words: Different wards, Different specimens, Klebsiella pneumoniae, Drug resistance rate

Li Liu, Meijie Jiang, Zhongmei Zhou. Analysis of drug resistance of Klebsiella pneumonia isolated from different specimens in hospital[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2019, 07(01): 31-34.

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References 11

1	魏绪廷，李庆芳，宗桂珍，等. 院内尿培养常见病原菌的耐药性分析[J/CD]. 中华实验和临床感染病杂志(电子版), 2015,9(1):49-52.
2	姜梅杰，牛淑香，宗桂珍，等. 血培养中常见病原菌的耐药性分析[J/CD]. 中华实验和临床感染病杂志(电子版), 2015,9(1):103-104.
3	刘佳丽，李震，刘静. 不同病房分离的肺炎克雷伯菌的耐药性及分布[J/CD]. 中华实验和临床感染病杂志(电子版), 2016,10(5):622-625.
4	胡付品，朱德妹，汪复，等. 2012年中国CHINET细菌耐药性监测[J]. 中国感染与化疗杂志, 2013,13(5):321-330.
5	胡付品，朱德妹，汪复，等. 2013年中国CHINET细菌耐药性监测[J]. 中国感染与化疗杂志, 2014,14(5):369-377.
6	胡付品，朱德妹，汪复，等. 2014年中国CHINET细菌耐药性监测[J]. 中国感染与化疗杂志, 2015,15(5):401-410.
7	胡付品，朱德妹，汪复，等. 2015年CHINET细菌耐药性监测[J]. 中国感染与化疗杂志, 2016,16(6):685-694.
8	周蓉，朱卫民，黄文祥，等. 855株肺炎克雷伯菌感染的临床分布及耐药性分析[J]. 中国抗生素杂志, 2013,38(5):363-369.
9	吕爽，孙志，鄢超，等. 1963株肺炎克雷伯菌的耐药性分析[J]. 中国实验诊断学, 2016,20(10):1744-1745.
10	梁丽霞，岑丽莲，赖汉瑜，等. 311株肺炎克雷伯菌感染分布及耐药分析[J]. 实验与检验医学, 2016,34(3):3755-3756.
11	邹自英，刘胜强，王琴，等. 不同标本来源的肺炎克雷伯菌耐药性特征研究[J]. 检验医学与临床, 2015,12(22):3300-3303.

抗菌药物	尿液(118株)		血液(58株)		痰液(445株)
抗菌药物	耐药菌株数	耐药率(%)	耐药菌株数	耐药率(%)	耐药菌株数	耐药率(%)
头孢唑啉	77	65.25	38	65.52	219	49.21
头孢呋辛	74	62.71	19	32.76	210	47.19
头孢噻肟	68	57.63	16	27.59	194	43.60
头孢他啶	46	38.98	12	20.69	120	26.97
头孢吡肟	57	48.31	14	24.14	168	37.08
头孢西丁	48	40.68	9	15.52	67	15.06
氨曲南	55	46.61	13	22.41	152	34.16
阿莫西林/克拉维酸	37	31.36	9	15.52	60	13.48
哌拉西林/他唑巴坦	15	12.71	5	8.62	35	7.87
美罗培南	9	7.63	3	5.17	27	6.07
厄他培南	9	7.63	3	5.17	27	6.07
亚胺培南	9	7.63	3	5.17	27	6.07
阿米卡星	17	14.41	3	5.17	24	5.39
妥布霉素	37	31.36	7	12.07	63	14.16
庆大霉素	43	36.44	13	22.41	109	24.49
左旋氧氟沙星	48	40.68	8	13.79	65	14.61
环丙沙星	58	49.15	11	18.97	77	17.30
复方新诺明	65	55.08	19	32.76	151	33.93

抗菌药物	尿液(118株)		血液(58株)		痰液(445株)
抗菌药物	耐药菌株数	耐药率(%)	耐药菌株数	耐药率(%)	耐药菌株数	耐药率(%)
头孢唑啉	77	65.25	38	65.52	219	49.21
头孢呋辛	74	62.71	19	32.76	210	47.19
头孢噻肟	68	57.63	16	27.59	194	43.60
头孢他啶	46	38.98	12	20.69	120	26.97
头孢吡肟	57	48.31	14	24.14	168	37.08
头孢西丁	48	40.68	9	15.52	67	15.06
氨曲南	55	46.61	13	22.41	152	34.16
阿莫西林/克拉维酸	37	31.36	9	15.52	60	13.48
哌拉西林/他唑巴坦	15	12.71	5	8.62	35	7.87
美罗培南	9	7.63	3	5.17	27	6.07
厄他培南	9	7.63	3	5.17	27	6.07
亚胺培南	9	7.63	3	5.17	27	6.07
阿米卡星	17	14.41	3	5.17	24	5.39
妥布霉素	37	31.36	7	12.07	63	14.16
庆大霉素	43	36.44	13	22.41	109	24.49
左旋氧氟沙星	48	40.68	8	13.79	65	14.61
环丙沙星	58	49.15	11	18.97	77	17.30
复方新诺明	65	55.08	19	32.76	151	33.93

抗菌药物	ICU病房(74株)		神经外病房(71株)		儿内科病房(143株)
抗菌药物	耐药菌株数	耐药率(%)	耐药菌株数	耐药率(%)	耐药菌株数	耐药率(%)
头孢唑啉	39	52.70	41	57.75	117	79.72
头孢呋辛	38	51.35	38	53.52	114	79.72
头孢噻肟	36	48.65	34	48.89	103	72.03
头孢他啶	24	32.42	11	15.49	90	62.94
头孢吡肟	30	40.54	31	43.66	103	72.03
头孢西丁	16	21.62	11	15.49	34	23.78
氨曲南	27	36.49	21	29.58	95	66.34
阿莫西林/克拉维酸	19	25.67	13	18.31	30	20.97
哌拉西林/他唑巴坦	13	17.57	8	11.28	16	11.19
美罗培南	11	14.86	6	8.45	12	8.39
厄他培南	11	14.86	6	8.45	12	8.39
亚胺培南	11	14.86	6	8.45	12	8.39
阿米卡星	12	16.22	5	7.04	5	3.50
妥布霉素	21	28.38	11	15.49	21	14.69
庆大霉素	30	40.54	18	25.35	55	38.46
左旋氧氟沙星	17	22.97	15	21.13	5	3.50
环丙沙星	22	29.73	18	25.35	9	5.29
复方新诺明	30	40.54	25	35.21	76	53.15

抗菌药物	ICU病房(74株)		神经外病房(71株)		儿内科病房(143株)
抗菌药物	耐药菌株数	耐药率(%)	耐药菌株数	耐药率(%)	耐药菌株数	耐药率(%)
头孢唑啉	39	52.70	41	57.75	117	79.72
头孢呋辛	38	51.35	38	53.52	114	79.72
头孢噻肟	36	48.65	34	48.89	103	72.03
头孢他啶	24	32.42	11	15.49	90	62.94
头孢吡肟	30	40.54	31	43.66	103	72.03
头孢西丁	16	21.62	11	15.49	34	23.78
氨曲南	27	36.49	21	29.58	95	66.34
阿莫西林/克拉维酸	19	25.67	13	18.31	30	20.97
哌拉西林/他唑巴坦	13	17.57	8	11.28	16	11.19
美罗培南	11	14.86	6	8.45	12	8.39
厄他培南	11	14.86	6	8.45	12	8.39
亚胺培南	11	14.86	6	8.45	12	8.39
阿米卡星	12	16.22	5	7.04	5	3.50
妥布霉素	21	28.38	11	15.49	21	14.69
庆大霉素	30	40.54	18	25.35	55	38.46
左旋氧氟沙星	17	22.97	15	21.13	5	3.50
环丙沙星	22	29.73	18	25.35	9	5.29
复方新诺明	30	40.54	25	35.21	76	53.15

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[2]	Wenlu Hang, Yongliang Du, Zhanjie Li, Haiquan Li, Jie Zhao, Yu Zhang. Carbapenem-resistant Klebsiella pneumoniae nosocomial infection in a patient with immunodeficiency [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2022, 16(03): 205-209.
[3]	Ziyan Shen, Shaoqing Lin, Xingran Du, Shuidi Zhao, Ganzhu Feng. Clinical characteristics and prognostic risk factors of hospital acquired Klebsiella pneumoniae bloodstream infection [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2020, 14(03): 198-205.
[4]	Ciyan Chen, Yan Du. Progress on hypervirulent Klebsiella pneumoniae [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2019, 13(02): 89-92.
[5]	Yuanyuan Duan, Jingrong Cao, Rong Min, Lili Zhang, Qiyan Zhao, Yuying Wang, Wei Xie, Peichang Wang. Clinical characteristics and antimicrobial resistance of bloodstream infections caused by Klebsiella pneumoniae in hospitalized patients [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(06): 698-702.
[6]	Jiali Liu, Zhen Li, Jing Liu. Drug resistance and clinical distribution of Klebsiella pneumoniae collected from different wards [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(05): 622-624.
[7]	Haochong Hu, Yiting Liu, Jiayu Guo, Jilin Zou, Zhongbao Chen, Jiangqiao Zhou, Tao Qiu. Treatment and analysis of carbapenem-resistant Klebsiella pneumoniae infection after renal transplantation [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(04): 246-249.
[8]	Wenlei Li, Jushan Wu, Zhe Jia, Na Pan, Wenyue Wu, Binwei Duan, Guangming Li. Risk factors of carbapenem-resistant Klebsiella pneumoniae infection after liver transplantation [J]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(06): 347-352.
[9]	jinlong Qu, Jun Guan, Zhaofen Lin. Two cases report of renal allograft artery rupture and hemorrhage caused by Klebsiella pneumoniae infection after renal transplantation [J]. Chinese Journal of Transplantation(Electronic Edition), 2018, 12(01): 39-41.
[10]	He Sun, Chunfeng He, Xiaodong Wu, Huize Han, Yi Shi, Qiang Li. Efficacy and safety analysis of Ceftazidime-Avibatam in carbapene-resistant Klebsiella pneumoniae infected patients with septic shock [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2021, 07(01): 76-80.
[11]	Jingjing Li, Lei Zhai, Haiping Zhao, Bo Zheng. Polycystic kidney disease complicated with cystic infection caused by multi-drug resistant Klebsiella pneumoniae: a case report and literature review [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(08): 920-923.
[12]	Weiqi Su, Wei Luo, Xiaoyan You. Phenotypic characteristics and drug resistance of Klebsiella pneumoniae [J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(09): 669-673.
[13]	Huiling Liang, Chao Han, Linying Zheng, Zhen Huang, Donghua Gao. Preliminary study on bacteriostatic-effect of Qiaoqinqingfei on Klebsiella pneumoniae and Staphylococcus aureus [J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2022, 10(01): 13-16.
[14]	Shuping Zhao, Meijie Jiang, Xia Chen. Drug resistance analysis of Escherichia coli isolated from different specimens in 2017 [J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2019, 07(04): 226-229.
[15]	Li Liu, Lin Li, Meijie Jiang. Mechanism of aminoglycoside resistance and molecular epidemiology of amikacin-resistant Klebsiella pneumoniae in hospital [J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2018, 06(01): 39-42.

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