Abstract:
Objective To investigate the value of abnormal prothrombin in the diagnosis of hepatitis B related hepatocellular carcinoma (HCC) and provide experimental evidence for its clinical application.
Methods The serum levels of PIVKA-Ⅱand alpha-fetoprotein in healthy subjects, hepatitis B-related benign diseases, and hepatitis B related hepatocellular carcinoma were measured, which had no abnormal coagulation function. ROC curves were used to analyze the value of the two methods in combination and unitaryin the diagnosis of hepatitis B related hepatocellular carcinoma.
Results PIVKA-Ⅱwas significantly higher in patients with hepatitis B related hepatocellular carcinoma than in healthy controls and benign liver diseases (P<0.05). The area under the ROC curve was 0.940; the sensitivity of the combined detection of AFP and hepatitis B was 94.9%, the specificity was 68.3%. The area under the curve of the combination was 0.947.
Conclusion PIVKA-Ⅱhas diagnostic value for hepatitis B related HCC, and its combined detection with AFP is more advantageous for the diagnosis of hepatitis B related HCC.For diagnostic use, PIVKA-Ⅱis most cost-effective in at-risk patients with normal levels of AFP in serum.
Key words:
PIVKA-Ⅱ,
AFP,
Hepatitis B related hepatocellular carcinoma
Hao Xi, Rongjing Liu. The application values of PIVKA-Ⅱ in diagnosing the hepatitis-related carcinoma[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2020, 08(04): 220-223.