The sudden outbreak of the novel coronavirus pneumonia in the first half of 2020 has brought challenges to the teaching of medical courses in colleges. Whole-body nucleic acid testing is carried out in many areas, and its detection principle comes from the teaching content of Molecular Diagnostics. It is a core course of medical laboratory technology with strong theoretical and practical application. The epidemic prevention and control has brought challenges to the teaching of medical courses in colleges and universities, as well as new concerns and teaching opportunities.Through specific teaching practices, this article explores the methods of conducting curriculum teaching in close integration with hot current events during the epidemic from four aspects: formulating teaching plans, optimizing teaching content, developing curriculum ideology, and guiding students to conduct scientific research. To explore the reform of course teaching in close combination with hot current events during the epidemic. At the same time, the teaching effect were evaluated and evaluated. Thoughts provide ideas and references for improving the teaching effect of Molecular Diagnostics in subsequent teaching implementation.