A case of human infection with Streptococcus suis disease with initial symptom of anaemia and fatigue

doi:10.3877/cma.j.issn.2095-5820.2024.01.009

Abstract

Abstract:

Objective

To report a case of Streptococcus suis infection with anemia and fatigue as the initial symptom in Tianmen City, analyze the source of infection and transmission route, and provide scientific basis for local epidemic prevention and control.

Methods

Streptococcus suis infection was confirmed by blood culture and epidemiological investigation was carried out.

Results

Blood culture of the patient was positive for Streptococcus suis type 2, and epidemiological investigation showed that Streptococcus suis was present in the slaughtering pig farm.

Conclusions

Slaughterhouse workers are susceptible to Streptococcus suis disease. It is necessary to strengthen the sanitary management of slaughterhouses, monitor the epidemic situation of pigs and standardize the personal protection to prevent the transmission and spread of human infection with Streptococcus suis disease.

Key words: anemia, Streptococcus suis, infective endocarditis, personal protection

Ying Wang, Mingchao Zhu, Qiong Yin. A case of human infection with Streptococcus suis disease with initial symptom of anaemia and fatigue[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(01): 43-47.

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References 31

1	TARINI N M A, SETIABUDY M, SUSILAWATHI N M, et al. Misidentification of S. suis as a zoonotic agent[J]. Open access macedonian journal of medical sciences, 2019, 7(14): 2309-2312.
2	李晓灵, 陈红, 李文俊, 等. 人感染猪链球菌病31例临床分析[J]. 四川医学, 2006(11): 1153-1154.
3	ZHANG B, KU X, YU X, et al. Prevalence and antimicrobial susceptibilities of bacterial pathogens in Chinese pig farms from 2013 to 2017[J]. Scientific reports, 2019, 9(1): 9908.
4	沈健, 孙建中, 尤玉民, 等. 如皋市人-猪链球菌感染综合征预防控制效果分析[J]. 数理医药学杂志, 2000(3): 257-258.
5	吕强, 吴建林, 袁珩, 等. 四川省人感染猪链球菌病流行病学调查分析[J]. 预防医学情报杂志, 2005(4): 379-383.
6	中国疾病预防控制中心. 全国人感染猪链球菌病监测方案（2009版）[EB/OL]. (2013-01-17)[2023-7-10].
7	马青, 刘英, 王月, 等. 贵州省死亡病例1型猪链球菌的分离及分子生物学特征分析[J]. 现代预防医学, 2018, 45(3): 506-509.
8	钟一鸣, 晏群, 李虹玲, 等. 人猪链球菌感染致脑膜炎1例[J]. 中国病原生物学杂志, 2014, 9(3): 292-293．
9	陈鲁鲁, 谭泽锋, 郭黎. 一例人感染猪链球菌病脑膜炎患者的诊治分析[J]. 临床合理用药杂志, 2016, 9(6): 119, 122.
10	张秋灵, 徐鹏, 刘瑶, 等. 人感染猪链球菌致细菌性脑膜炎1例并文献复习[J]. 内科急危重症杂志, 2019, 25(6): 527-528.
11	郑伟, 孙继梅, 周秀珍, 等. 人感染猪链球菌Ⅱ型化脓性脑膜炎1例分析[J]. 中国误诊学杂志, 2009, 9(3): 724-725.
12	田丽红, 陈旭艳, 董志高, 等. 脑膜炎型人猪链球菌感染合并败血症1例[J]. 检验医学与临床, 2020, 17(23): 3547-3549.
13	侯贞德. 晚发型无乳链球菌感染致败血症、化脓性脑膜炎合并硬膜下积脓1例[D]. 石家庄：河北医科大学, 2020.
14	梁小英, 王莉宁. 人感染猪链球菌致脑膜炎败血症1例[J]. 中国医药指南, 2012, 10(21): 633-634.
15	HUONG V T, HA N, HUY N T, et al. Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans[J]. Emerging infectious diseases, 2014, 20(7): 1105-1114.
16	陆乔. 人感染猪链球菌Ⅱ型致败血症1例[J]. 医学理论与实践, 2019, 32(6): 882-883.
17	周淑琴, 孙韶华. 蓬莱市新发1例人感染猪链球菌病例流行病学调查[J]. 河南预防医学杂志, 2020, 31(12): 928-930, 939.
18	董德平, 韩立中, 项明洁, 等. 猪链球菌Ⅱ型致败血症一例[J]. 中华医学检验杂志, 1999(2): 8.
19	盛春田, 李宜良. 猪链球菌病的流行特点、症状和中西医治疗[J]. 中国动物保健, 2022, 24(4): 28-29.
20	王海峰, 李亚飞, 张白帆, 等. 河南省5起人感染猪链球菌病疫情特征分析[J]. 河南预防医学杂志, 2022, 33(9): 647-649, 677.
21	朱伟芳, 李炎冬, 陈俭. 以暴发性紫癜为首发症状的人感染猪链球菌一例[J]. 中华急诊医学杂志, 2020, 29(9): 1235-1236.
22	ZHENG H, QIU X, ROY D, et al. Genotyping and investigating capsular polysaccharide synthesis gene loci of non-serotypeable Streptococcus suis isolated from diseased pigs in Canada[J]. Veterinary research, 2017, 48(1): 10.
23	马惠东, 金亮, 万凤英, 等. 猪链球菌致化脓性脑膜炎1例[J]. 中国感染与化疗杂志, 2018, 18(2): 201-202.
24	邱海波. 重视猪链球菌Ⅱ型感染的治疗[J]. 中华急诊医学杂志, 2005(11): 9-10.
25	曾桂芬, 刘行超, 李世花, 等. 2例人感染猪链球菌病临床分析[J]. 检验医学与临床, 2014, 11(7): 1006-1007.
26	廖虹瑜, 李文博, 何树森, 等. 2006-2017年四川省临床分离猪链球菌2型的病原学特征[J]. 中国人兽共患病学报, 2021, 37(4): 306-310, 322.
27	熊火梅, 罗菲, 徐秋琴. 九江市首例人感染猪链球菌病的病原学特征分析[J]. 临床检验杂志, 2022, 40(5): 371-373.
28	CHEN L, SONG Y, WEI Z, et al. Antimicrobial susceptibility, tetracycline and erythromycin resistance genes, and multilocus sequence typing of Streptococcus suis isolates from diseased pigs in China[J]. The journal of veterinary medical science, 2013, 75(5): 583-587.
29	蔡田, 罗行炜, 徐引第, 等. 猪链球菌对大环内酯类抗生素的耐药性研究[J]. 河南农业大学学报, 2019, 53(1): 73-81.
30	秦丹丹. 夏季猪链球菌病综合防治措施[J]. 畜牧兽医科技信息, 2021(11): 131-132.
31	黄航, 赵春颖, 杨福. 猪链球菌病防控[J]. 畜牧兽医科学（电子版）, 2021(16): 58-59.

项目	2月15日	2月21日	2月26日	3月1日	3月7日	3月11日
WBC/（×10⁹/L）	12.34	10.38	21.39	12.13	7.90	6.80
HGB/（g/L）	90.00	100.00	82.00	95.00	87.00	100.00
PLT/（×10⁹/L）	294.00	419.00	325.00	226.00	304.00	480.00
NEU%/%	92.10	80.60	95.90	86.70	83.10	76.70
淋巴细胞百分比（LYM%）/%	4.00	12.50	0.50	5.30	8.80	11.60
CRP/（mg/L）	72.14	25.54	14.80	149.40	23.80	17.10
降钙素原（PCT）/（ng/ml）	0.171 0	0.061 2	0.270 0	0.290 0	<0.05	<0.05

项目	2月15日	2月21日	2月26日	3月1日	3月7日	3月11日
WBC/（×10⁹/L）	12.34	10.38	21.39	12.13	7.90	6.80
HGB/（g/L）	90.00	100.00	82.00	95.00	87.00	100.00
PLT/（×10⁹/L）	294.00	419.00	325.00	226.00	304.00	480.00
NEU%/%	92.10	80.60	95.90	86.70	83.10	76.70
淋巴细胞百分比（LYM%）/%	4.00	12.50	0.50	5.30	8.80	11.60
CRP/（mg/L）	72.14	25.54	14.80	149.40	23.80	17.10
降钙素原（PCT）/（ng/ml）	0.171 0	0.061 2	0.270 0	0.290 0	<0.05	<0.05

项目	2月17日	2月27日	2月28日	3月1日	3月7日
BNP/（pg/ml）	8 605.00	5 160.00	4 150.00	2 210.00	399.40
hs-TnI/（pg/ml）	92.50	4 708.50	2 181.80	1 020.50	267.40

项目	2月17日	2月27日	2月28日	3月1日	3月7日
BNP/（pg/ml）	8 605.00	5 160.00	4 150.00	2 210.00	399.40
hs-TnI/（pg/ml）	92.50	4 708.50	2 181.80	1 020.50	267.40

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