In January 2024, the International Council for Standardization in Hematology (ICSH) released the "ICSH guidance for internal quality control policy for hematology analyzers". Based on current practices and requirements for internal quality control in different countries, as well as the diversity of laboratory practice and recommendations from commercial internal quality control providers, the guidance provides recommendations on quality control methods, sources and concentration levels of control materials, quality control frequency, and statistical decision rules. This article interprets the guidance and in line with the requirements of China's industry standard WS/T 641-2018, focuses on the selection of control materials and concentration levels, quality control frequency, and statistical interpretation rules for hematology analyzers, aiming to help medical laboratories and manufacturers better understand and apply the guidance.