Visualization analysis of research status and hotspots of liquid chromatography-tandem mass spectrometry in blood concentration detection

doi:10.3877/cma.j.issn.2095-5820.2026.03.002

Abstract

Abstract:

Objective

To conduct a bibliometric visualization analysis of research on liquid chromatography-tandem mass spectrometry (LC-MS/MS) in blood concentration detection using Chinese databases, aiming to reveal its research status, evolution trajectory and frontier hotspots.

Methods

Relevant literature was systematically retrieved from the CNKI, the VIP Chinese Journal Service Platform, and Wan fang Database. Visualization analysis was performed using CiteSpace 6.3.R1 software.

Results

A total of 2743 articles were included, with annual publication volume showing a phased characteristic of slow growth, rapid increase and subsequent stabilization. The top three institutions by publication volume were China Pharmaceutical University, the Second Xiangya Hospital of Central South University, and Central South University. The main contributing authors were research teams led by Wen Yuguan and Wen Aidong as core members. Keywords with high frequency included "pharmacokinetics", "LC-MS/MS" and "blood drug concentration". Keyword evolution analysis indicated that the research has progressed through three stages: Methodology establishment, application expansion and clinical precision. Current hotspots focus on therapeutic drug monitoring, ultra-performance liquid chromatography-tandem mass spectrometry and personalized medication research targeting specific drugs and populations.

Conclusions

LC-MS/MS technology has become an indispensable core analytical platform for blood drug concentration detection. The research system is mature and continuously deepening its integration into clinical practice. Future efforts should strengthen collaboration among institutions and authors, continuously improve techniques, refine methodological standardization, and expand application scenarios to further promote the development of individualized drug therapy.

Key words: LC-MS/MS, blood concentration, therapeutic drug monitoring, visualization analysis

Tianyuan Zheng, Jun Zhang, Xiaojing Li, Peipei Zhou, Shuhong Liang, Baohong Yue. Visualization analysis of research status and hotspots of liquid chromatography-tandem mass spectrometry in blood concentration detection[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2026, 14(03): 190-198.

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Figures/Tables 11

References 31

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序号	机构	发文量/篇	发文最早年份/年
1	中国药科大学	168	1999
2	中南大学湘雅二医院	66	2003
3	中南大学	65	2003
4	沈阳药科大学	60	2001
5	南京中医药大学	37	2003
6	广州市脑科医院	30	2006
7	华中科技大学同济医学院附属同济医院	30	2007
8	军事医学科学院	29	2004
9	四川大学华西医院	28	2008
10	中南大学湘雅三医院	27	2004

序号	机构	发文量/篇	发文最早年份/年
1	中国药科大学	168	1999
2	中南大学湘雅二医院	66	2003
3	中南大学	65	2003
4	沈阳药科大学	60	2001
5	南京中医药大学	37	2003
6	广州市脑科医院	30	2006
7	华中科技大学同济医学院附属同济医院	30	2007
8	军事医学科学院	29	2004
9	四川大学华西医院	28	2008
10	中南大学湘雅三医院	27	2004

序号	关键词	频次/次	中心性
1	药代动力学	1429	0.91
2	液相色谱-串联质谱	1243	0.50
3	血药浓度	947	0.45
4	生物等效性	377	0.08
5	超高效液相色谱-串联质谱	159	0.04
6	治疗药物监测	132	0.03
7	液相色谱	117	0.03
8	生物利用度	95	0.02
9	血浆	92	0.03
10	大鼠	77	0.02
11	色谱法	72	0.01
12	代谢物	47	0.02
13	串联质谱	46	0.01
14	伏立康唑	42	0.01

序号	关键词	频次/次	中心性
1	药代动力学	1429	0.91
2	液相色谱-串联质谱	1243	0.50
3	血药浓度	947	0.45
4	生物等效性	377	0.08
5	超高效液相色谱-串联质谱	159	0.04
6	治疗药物监测	132	0.03
7	液相色谱	117	0.03
8	生物利用度	95	0.02
9	血浆	92	0.03
10	大鼠	77	0.02
11	色谱法	72	0.01
12	代谢物	47	0.02
13	串联质谱	46	0.01
14	伏立康唑	42	0.01

聚类名称	节点数	年份	聚类标签	关键词
#0	233	2011	血药浓度	血药浓度、色谱法、不确定度、液相色谱-串联质谱法、高压液相
#1	206	2014	药代动力学	药代动力学、药动学、血药浓度、LC-MS/MS、黄芩苷
#2	122	2017	治疗药物监测	治疗药物监测、伏立康唑、超高效液相色谱-串联质谱法、药代动力学、血药浓度监测
#3	105	2010	生物等效性	生物等效性、血药浓度、健康受试者、安全性、空腹
#4	89	2009	色谱法	色谱法、高压液相、串联质谱法、质量法、光谱法
#5	70	2015	精神分裂症	精神分裂症、利培酮、基因多态性、丙戊酸、疗效
#6	69	2009	血浆	血浆、测定、含量测定、血浆样品、甘草次酸
#7	62	2014	大鼠	大鼠、药物相互作用、毒代动力学、药效学、血药浓度
#8	28	2014	比格犬	比格犬、人参皂苷rg1、人参皂苷re、人参皂苷rb1、beagle犬
#9	20	2010	舒芬太尼	舒芬太尼、麻醉、体外循环、腹部手术、老年人

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