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Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2020, Vol. 08 ›› Issue (03): 145-149. doi: 10.3877/cma.j.issn.2095-5820.2020.03.004

Special Issue:

• Clinical Research • Previous Articles     Next Articles

Establish and validate the prognosis model of sepsis patients by ultra-early vital signs and lactate level

Qilin Yang1, Wendi Liang2, Fuhua Xie1, Zhenghui Zhang1, Xuming Xiong1, Weiyan Chen1,()   

  1. 1. Department of Critical Care Medicine, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
    2. Guangzhou Medical University, Guangzhou 510260, China
  • Received:2020-04-03 Online:2020-08-28 Published:2020-08-28
  • Contact: Weiyan Chen
  • About author:
    Corresponding author: Chen Weiyan, Email: .

Abstract:

Objective

To establish and validate a nomogram scoring system to evaluate the severity of the sepsis patient.

Methods

Clinical application scenarios clinical data available within 1 hour of admission to the ICU was used to establish the nomogram scoring system. Clinical predictors included age, sex, vital signs, vasopressor use and lactate level within 1 hour. 30-day mortality as an outcome. Logistic regression analysis model was used to determine independent risk factors and a nomogram was established to predict 30-day mortality.The validation was performed using repeated sampling method.

Results

A nomogram of 30-day mortality was established in sepsis patients with a C-index of 0.759 (95% CI: 0.725~0.794) and a validated discriminant C-index of 0.762 (95% CI: 0.728~0.797) using repeated sampling methods.

Conclusion

Nomogram model will clinically be relevant for ultra-early determination of prognosis and severity of sepsis and has clinical significance. However, this model needs to be further validated.

Key words: Sepsis, Prognostic model, Vital signs, Lactate

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