To analyze the expression of CD64,CD11b and lymphocyte subsets in peripheral blood from different kinds of infectious diseases.

40 cases of bacterial infection (bacterial group) including 20 cases of whole blood infection and 20 cases of local infection, 20 patients infected with Epstein-Barr virus (virus group) and 20 healthy subjects (control group) were selected. Flow cytometry was used to detect the lymphocyte subsets and the expression of CD64、CD11b in peripheral blood.

The expression of CD64 and the ratio of B cells in the bacterial group were significantly higher than that in the virus group and control group (P＜0.05). The expression of CD11b in neutrophiles and monocytes and the ratio of CD3^＋T cells were increased in virus group by comparing with bacterial group (P＜0.05), and the expression of CD11b in these groups were higher than that in control group. The ratio of CD8^＋T cells in the virus group was much higher than that in the other two groups (P＜0.05). The DN-T cells in bacterial group was much lower than that in virus group and control group (P＜0.05).Two groups of The ratio of NK cells was reduced in virus and bacterial groups to some extent and was lower than the control group,but the difference was not significant (P＞0.05).The ratio of DP-T cell among the groups had no significant difference (P＞0.05). In the bacterial group, there was no statistical difference in the above indexes between the systemic infection group and the local infection group (P＞0.05).

The detection of the expression of CD64 in neutrophile is meaningful in the diagnosis of bacterial infection.The expression of CD11b in neutrophiles and monocytes can be increased during infection, and the increase is more obvious for viral infection. Combined detection of lymphocyte subsets can evaluate the status of immune function of patients, and provide reliable reference and basis for the treatment of patients with clinical infection.