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Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2026, Vol. 14 ›› Issue (03): 217-226. doi: 10.3877/cma.j.issn.2095-5820.2026.03.005

• Review • Previous Articles    

Research progress and application prospects of artificial intelligence in hematology analyzers re-examination workflow

Yongjian He1, Xinzhong Wu2, Jianfeng Hang3, Ya Gao1, Taixue An1, Yuting Wang4, Dehua Sun1,()   

  1. 1 Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou Guangdong 510515, China
    2 Department of Clinical Laboratory, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou Guangdong 510120, China
    3 Department of Clinical Laboratory, General Hospital of Southern Theater Command of the Chinese People's Liberation Army, Guangzhou Guangdong 510010, China
    4 AI Laboratory Division, Shenzhen Dymind Biotechnology Co., Ltd., Shenzhen Guangdong 518106, China
  • Received:2026-06-11 Online:2026-08-28 Published:2026-08-28
  • Contact: Dehua Sun

Abstract:

Hematology analyzers serve as the most fundamental and widely used disease screening tool in clinical practice, offering a multidimensional detection system that provides numerical results such as complete blood count, white blood cell differential count and cell population data (CPD), alongside graphical data including scattergrams and histograms. However, universal review criteria based on cell counts and instrument flags fail to adapt to the specimen characteristics of different medical institutions, thus resulting in high false-negative risks and a heavy review burden. In recent years, artificial intelligence (AI) has achieved breakthrough advances in medical image recognition, providing a novel approach for the intelligent analysis of hematological graphical data. This paper systematically examines the feasibility of integrating multidimensional signal features from hematology analyzers with traditional review criteria, and divides the development of AI-assisted re-examination workflow into 4 stages: Traditional rule implementation, feature-parameter modeling, intelligent graphical data analysis, and multimodal data fusion. It elaborates on CPD-based machine learning screening methods, the strengths of deep learning in graphical analysis, and the clinical efficacy of multimodal fusion, while analyzing core challenges including the scarcity of high-quality datasets, the algorithmic "black box" issue, and the lack of standardized evaluation frameworks. Looking ahead, the construction of an integrated intelligent review system incorporating numerical parameters, graphical features and clinical information will enhance the detection capacity for abnormal specimens via human-machine collaboration, thereby reducing unnecessary manual reviews.

Key words: hematology analyzers, artificial intelligence, re-examination workflow, cell population data, multi-modal fusion

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