广州地区体检人群维生素D水平分析

doi:10.3877/cma.j.issn.2095-5820.2020.04.008

目的

对广州地区体检人群25羟基维生素D [25(OH)D] 检查结果进行分析，了解各类人群25(OH)D水平状况，辅助诊断因维生素D缺乏引起的相关疾病。

方法

使用化学发光法测定2016年1月至2019年1月共9 163例体检者血清25(OH)D水平，分别比较不同性别、年龄人群25(OH)D营养水平。

结果

9 163例体检者血清25(OH)D的平均水平为63.89 nmol/L，正常率为26.41%，不足率为46.45%，缺乏率为27.14%。男性25(OH)D总体正常率为29.29%，不足率为47.36%，缺乏率为23.28%；女性25(OH)D总体正常率为23.26%，不足率为45.42%，缺乏率为31.32%。女性群体25(OH)D缺乏率高于男性，差异有统计学意义(P=0.000)。男女体检群体中25(OH)D缺乏率最高的均为20岁~29岁年龄段，分别为28.75%、42.71%。对不同月份维生素D水平进行分析，发现血清25(OH)D水平最高为5月，最低为2月。

结论

广州地区人群存在不同程度的25(OH)D缺乏，且女性相比男性有更高的缺乏率。

关键词: 25羟基维生素D, 维生素D缺乏率, 体检人群

Objective

The aim of this study was to help diagnose diseases caused by Vitamin D deficiency by analyzing the 25-hydroxyvitamin D [25(OH)D] level in people taking physical examination in Guangzhou.

Methods

The serum 25(OH)D levels were determined by chemiluminescent assayin 9 163 physical examination subjects from January 2016 to January 2019, and 25(OH)D nutritional levels were compared among different genders and age groups.

Results

Mean serum 25(OH)D level of 9 163 subjects was 63.89 nmol/L. Subjects with adequate, inadequate and deficient serum 25(OH)D took percentage of 26.41%, 46.45% and 27.14%, respectively. Male subjects with adequate, inadequate and deficient serum 25(OH)D took percentage of 29.29%, 47.36% and 23.28%, respectively. Female subjects with adequate, inadequate and deficient serum 25(OH)D took percentage of 23.26%, 45.42% and 31.32%, respectively. Serum 25(OH)D deficiency in female subjects was higher than that in male subjects. The difference in this study has statistical significance (P=0.000).The highest 25(OH)D deficiency rate in male and female physical examination groups were in the 20~29 age group(28.75% and 42.71%, respectively). Analysis on vitamin D levels in different months indicated that the highest level of serum 25(OH)D appears in May, while the lowest appears in February.

Conclusion

There are different levels of 25 (OH) D deficiency in people living Guangzhou, and women have a higher rate of deficiency than men.

Key words: 25-hydroxyvitamin D, Vitamin D deficiency rate, Physical examination population

表1 不同性别一般资料分析

性别	n(%)	25(OH)D平均水平±SD，nmol/L
男性	4773（52.10）	65.83±22.68
女性	4390（47.90）	61.50±22.40
P		0.020

表1 不同性别一般资料分析

性别	n(%)	25(OH)D平均水平±SD，nmol/L
男性	4773（52.10）	65.83±22.68
女性	4390（47.90）	61.50±22.40
P		0.020

表2 各年龄段人群血清25(OH)D水平

指标		总体		缺乏		不足		正常
指标		n(%)	(±SD，nmol/L)	n(%)	(±SD，nmol/L)	n(%)	(±SD，nmol/L)	n(%)	(±SD，nmol/L)
	总体	9163	63.89±23.21	2487(27.14)	39.30±7.72	4256(46.45)	61.68±6.93	2420(26.41)	92.35±19.13
	男性	4773(52.00)	65.83±22.68	1112(23.28)	39.91±7.51	2262(47.36)	62.03±6.88	1399(29.29)	92.57±19.02
年龄段(岁)
	20~29	393(8.20)	59.53±15.77^*	113(28.75)	41.60±6.94	212(53.94)	61.23±6.44	68(17.30)	84.57±7.56
	30~39	768(16.10)	64.61±19.51^*	156(20.31)	41.49±6.28	414(53.91)	61.42±6.77	198(25.78)	89.50±16.96
	40~49	1216(25.50)	64.65±20.95^*	291(23.93)	39.42±7.49	580(47.70)	62.18±7.00	345(28.37)	90.10±14.93
	50~59	1470(30.80)	67.39±25.10^*	353(24.00)	39.64±7.35	640(43.51)	62.14±6.97	477(32.43)	94.97±21.64
	≥60	928(19.40)	68.54±24.98^*	199(21.44)	38.93±8.66	416(44.83)	62.68±6.84	311(33.51)	95.32±20.56
	女性	4390(48.00)	61.50±22.40	1375(31.32)	39.12±7.78	1994(45.42)	61.29±6.97	1021(23.26)	92.06±18.94
年龄段(岁)
	20~29	377(8.60)	54.33±17.12	161(42.71)^▽	39.87±6.93	172(45.62)	59.30±6.94	44(11.67)	87.77±12.84
	30~39	623(14.20)	58.51±19.03	226(36.28)^▽	41.02±6.73	292(46.87)	60.61±7.20	105(16.85)	90.32±14.94
	40~49	935(21.30)	61.87±22.23	270(28.88)^▽	38.33±8.20	454(48.56)	61.71±6.76	211(22.57)	92.33±19.21
	50~59	1515(34.50)	64.52±23.47	397(26.20)^▽	38.75±7.58	689(45.48)	61.54±6.97	429(28.32)	93.15±19.13
	≥60	940(21.40)	61.15±23.81	321(34.15)^▽	38.55±8.52	387(41.17)	61.74±6.86	232(24.68)	91.42±22.25

表2 各年龄段人群血清25(OH)D水平

指标		总体		缺乏		不足		正常
指标		n(%)	(±SD，nmol/L)	n(%)	(±SD，nmol/L)	n(%)	(±SD，nmol/L)	n(%)	(±SD，nmol/L)
	总体	9163	63.89±23.21	2487(27.14)	39.30±7.72	4256(46.45)	61.68±6.93	2420(26.41)	92.35±19.13
	男性	4773(52.00)	65.83±22.68	1112(23.28)	39.91±7.51	2262(47.36)	62.03±6.88	1399(29.29)	92.57±19.02
年龄段(岁)
	20~29	393(8.20)	59.53±15.77^*	113(28.75)	41.60±6.94	212(53.94)	61.23±6.44	68(17.30)	84.57±7.56
	30~39	768(16.10)	64.61±19.51^*	156(20.31)	41.49±6.28	414(53.91)	61.42±6.77	198(25.78)	89.50±16.96
	40~49	1216(25.50)	64.65±20.95^*	291(23.93)	39.42±7.49	580(47.70)	62.18±7.00	345(28.37)	90.10±14.93
	50~59	1470(30.80)	67.39±25.10^*	353(24.00)	39.64±7.35	640(43.51)	62.14±6.97	477(32.43)	94.97±21.64
	≥60	928(19.40)	68.54±24.98^*	199(21.44)	38.93±8.66	416(44.83)	62.68±6.84	311(33.51)	95.32±20.56
	女性	4390(48.00)	61.50±22.40	1375(31.32)	39.12±7.78	1994(45.42)	61.29±6.97	1021(23.26)	92.06±18.94
年龄段(岁)
	20~29	377(8.60)	54.33±17.12	161(42.71)^▽	39.87±6.93	172(45.62)	59.30±6.94	44(11.67)	87.77±12.84
	30~39	623(14.20)	58.51±19.03	226(36.28)^▽	41.02±6.73	292(46.87)	60.61±7.20	105(16.85)	90.32±14.94
	40~49	935(21.30)	61.87±22.23	270(28.88)^▽	38.33±8.20	454(48.56)	61.71±6.76	211(22.57)	92.33±19.21
	50~59	1515(34.50)	64.52±23.47	397(26.20)^▽	38.75±7.58	689(45.48)	61.54±6.97	429(28.32)	93.15±19.13
	≥60	940(21.40)	61.15±23.81	321(34.15)^▽	38.55±8.52	387(41.17)	61.74±6.86	232(24.68)	91.42±22.25

表3 各月份体检人群血清25(OH)D水平

月份	总体		男性		女性
月份	n	(±SD，nmol/L)	n	(±SD，nmol/L)	n	(±SD，nmol/L)
1	598	60.50±21.48	333	62.09±20.29	265	58.52±22.77
2	547	58.01±23.90	282	59.93±26.42	265	55.96±20.72
3	715	64.37±25.92	386	65.43±24.22	329	63.12±27.77
4	359	58.59±26.74	170	61.44±26.34	189	55.94±26.94
5	418	77.85±25.00	219	80.19±25.50	199	75.29±24.23
6	853	69.88±19.84	494	71.23±19.90	359	68.01±19.63
7	529	67.49±23.88	268	68.71±25.17	261	66.23±22.46
8	392	74.46±27.97	183	75.73±30.13	209	73.34±25.96
9	1725	58.68±22.38	839	60.87±24.72	886	56.60±19.70
10	676	62.06±20.22	330	64.97±20.76	346	59.28±19.31
11	1356	62.14±18.08	704	64.16±17.21	652	59.96±18.74
12	995	66.39±23.93	565	69.50±24.50	430	62.32±22.54

表3 各月份体检人群血清25(OH)D水平

月份	总体		男性		女性
月份	n	(±SD，nmol/L)	n	(±SD，nmol/L)	n	(±SD，nmol/L)
1	598	60.50±21.48	333	62.09±20.29	265	58.52±22.77
2	547	58.01±23.90	282	59.93±26.42	265	55.96±20.72
3	715	64.37±25.92	386	65.43±24.22	329	63.12±27.77
4	359	58.59±26.74	170	61.44±26.34	189	55.94±26.94
5	418	77.85±25.00	219	80.19±25.50	199	75.29±24.23
6	853	69.88±19.84	494	71.23±19.90	359	68.01±19.63
7	529	67.49±23.88	268	68.71±25.17	261	66.23±22.46
8	392	74.46±27.97	183	75.73±30.13	209	73.34±25.96
9	1725	58.68±22.38	839	60.87±24.72	886	56.60±19.70
10	676	62.06±20.22	330	64.97±20.76	346	59.28±19.31
11	1356	62.14±18.08	704	64.16±17.21	652	59.96±18.74
12	995	66.39±23.93	565	69.50±24.50	430	62.32±22.54

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Analysis of vitamin D level in people taking physical examination in Guangzhou

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Analysis of vitamin D level in people taking physical examination in Guangzhou