回顾性分析佛山市健康成人血尿素（Urea）、肌酐（Cr）检验结果，初步建立佛山地区健康成人Urea、Cr参考区间。

随机选取2021年3月1日至2021年8月31日佛山复星禅诚医院体检中心健康体检者10 412人，采用贝克曼AU5800全自动生化分析仪检测Urea、Cr、空腹血糖（FPG）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、尿酸（UA），分析Urea、Cr分布特点以及性别、年龄、FPG、TC、TG、HDL-C、LDL-C、UA对Urea与Cr的影响，初步建立佛山地区生物参考区间。

10 412名研究对象根据FPG、TC、TG、HDL-C、LDL-C、UA实验室参考区间及剔除Urea、Cr离群值进行筛选，符合本次研究对象2267名。对2267名研究对象分析结果显示佛山地区血清Urea、Cr参考区间设定男性以60岁为分界线，女性以50岁为分界线；血清Urea参考区间为男性＜60岁：4.61（2.91，7.21）mmol/L，男性≥60岁：5.42（3.35，8.46）mmol/L；女性＜50岁：3.89（2.43，6.15）mmol/L，女性≥50岁：4.76（2.84，8.06）mmol/L；血清Cr参考区间为男性＜60岁：83（65，104）μmol/L，男性≥60岁：84（63，122）μmol/L；女性＜50岁：58（45，74）μmol/L，女性≥50岁：63（46，92）μmol/L。

佛山地区健康成人不同性别、年龄之间Urea与Cr生物参考区间并不相同，应按性别、年龄分别设立生物参考区间。

To analyze factors that influence serum Urea and creatinine (Cr) of adults in Foshan, and establish a preliminary reference interval for adult serum Urea and Cr.

A total of 10 412 persons who conducted physical examination between March 1 and August 31, 2021 at the physical examination center of the Foshan Fosun Chancheng Hospital were randomly selected. The serum Urea, Cr, fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and uric acid (UA) were measured by Beckman AU5800 automatic biochemical analyzer. The distribution characteristics of Urea and Cr, as well as the mutual influence of gender, age, FPG, TC, TG, HDL-C, LDL-C, and UA on Urea and Cr were analyzed. The medical reference intervals of serum Urea and Cr were established.

Laboratory reference intervals of FPG, TC, TG, HDL-C, LDL-C, and UA were used to screen research subjects. In addition, subjects with outliers in Urea and Cr were also excluded. A total of 2267 in 10 412 subjects were eligible for this study. Analysis of 2267 subjects showed that the reference interval of serum Urea and Cr in Foshan can be subdivided by the age of 60 in male, and the age of 50 in female. The reference interval of serum Urea in male >60 years: 4.61 (2.9, 7.21) mmol/L, in male ≥60 years: 5.42 (3.35, 8.46) mmol/ L; in female <50 years: 3.89 (2.43, 6.15) mmol/L, in female ≥50 years: 4.76 (2.84, 8.06) mmol/L; the reference interval of serum Cr in male <60 years: 83 (65, 104) μmol/L, in male ≥60 years: 84 (63, 122) μmol/L; in female <50 years: 58 (45, 74) μmol/L, in female ≥50 years: 63 (46, 92) μmol/L.

The reference intervals for serum urea and creatinine of healthy adults in Foshan are not the same among different genders and ages. Reference intervals should be set up according to gender and age.