通过探讨尿液中阿莫西林-克拉维酸钾结晶的特征，有助于在日常检验工作中及早发现药物结晶，为临床安全用药提供参考。

观察阿莫西林-克拉维酸钾结晶的形态特征并进行理化实验，再结合国内外相关文献，和尿液中其他形态相似的结晶进行鉴别区分。

确认3例患者尿液中的结晶为阿莫西林-克拉维酸钾结晶。

超剂量使用阿莫西林-克拉维酸钾患者的尿液中容易析出药物结晶。检验人员遇见类似针形结晶时，应考虑药物因素，要及时与临床医生沟通，询问用药情况，提示医生注意用药剂量，警惕尿液出现药物结晶的不良反应，防范因药物引起的肾损伤。

To help inspectors to detect the crystals of the drug early in daily testing and provide a reference for clinical safety medication by exploring the characteristics of amoxicillin-clavulanate crystals in urine.

The morphological characteristics of amoxicillin-clavulanate crystals were observed and the physicochemical tests were carried out. Combined with relevant domestic and foreign literatures, other crystals with similar morphology in urine were identified and distinguished.

Amoxicillin-clavulanate potassium crystals were confirmed in the urine of 3 patients.

The crystal of amoxicillin-clavulanate potassium is more likely to precipitate from the urine of patients with overdose of amoxicillin-clavulanate potassium. When similar needle-shaped crystals are found, the inspector should consider the adverse reactions of amoxicillin-clavulanate potassium, communicate with the clinician in time, ask about the medication, and prompt clinicians to pay attention to the dose of medication to prevent patients from renal injuries due to excessive medication.